Lomsky Milan, Richter Jens, Johansson Lena, Høilund-Carlsen Poul F, Edenbrandt Lars
Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Clin Physiol Funct Imaging. 2006 May;26(3):139-45. doi: 10.1111/j.1475-097X.2006.00667.x.
We recently presented a new method for quantification of CArdiac FUnction--denoted CAFU--as the first step in the development of an automated method for integrated interpretation of gated myocardial perfusion single photon emission computed tomography (SPECT) images. The aim of this study was to validate CAFU in the assessment of global and regional function of the left ventricle. Quantitative gated-SPECT (QGS), the most widely used software package for quantification of gated-SPECT images, was used as reference method for the measurements of ejection fraction (EF) and ventricular volumes, and visual analysis by an experienced physician was used as reference method for the measurements of regional wall motion and thickening. Two different groups of consecutive patients referred for myocardial perfusion scintigraphy were studied. Global function was evaluated in 316 patients and regional function in 49 other patients. The studies were performed using a 2-day stress/rest 99 m-Tc-sestamibi protocol. A good correlation was found between EF values from QGS and CAFU (EF CAFU = 0.84 EF QGS + 13, r = 0.94), but CAFU values were on average 4 EF points higher than QGS values. With CAFU the segments with normal thickening according to the physician showed significantly higher thickening values (in all parts of the myocardium) compared to the segments classified as having abnormal thickening. In conclusion, this study demonstrates that CAFU can be used to quantify global and regional function in gated-SPECT images. This is an important step in our development of an automated method for integrated interpretation of gated-SPECT myocardial perfusion scintigraphy studies.
我们最近提出了一种用于量化心脏功能的新方法——称为CAFU，作为开发门控心肌灌注单光子发射计算机断层扫描（SPECT）图像综合解释自动化方法的第一步。本研究的目的是在评估左心室整体和局部功能中验证CAFU。定量门控SPECT（QGS）是用于量化门控SPECT图像的最广泛使用的软件包，用作测量射血分数（EF）和心室容积的参考方法，由经验丰富的医生进行的视觉分析用作测量局部壁运动和增厚的参考方法。对两组连续转诊进行心肌灌注闪烁显像的患者进行了研究。对316例患者评估了整体功能，对另外49例患者评估了局部功能。研究采用2天的负荷/静息99m锝-甲氧基异丁基异腈方案进行。发现QGS和CAFU的EF值之间具有良好的相关性（EF CAFU = 0.84 EF QGS + 13，r = 0.94），但CAFU值平均比QGS值高4个EF点。与被分类为增厚异常的节段相比，根据医生判断增厚正常的节段在CAFU下显示出显著更高的增厚值（在心肌的所有部位）。总之，本研究表明CAFU可用于量化门控SPECT图像中的整体和局部功能。这是我们开发门控SPECT心肌灌注闪烁显像研究综合解释自动化方法的重要一步。
