Neipp Michael, Schwarz Anke, Pertschy Stefanie, Klempnauer Jürgen, Becker Thomas
Klinik für Allgemein, Viszeral und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany.
Clin Transplant. 2006 Mar-Apr;20(2):147-50. doi: 10.1111/j.1399-0012.2005.00455.x.
Transmission of cancer is a fatal risk in organ transplantation. We present a case of incidental renal carcinoma in a kidney obtained from a living donor. A 56-yr-old father was evaluated for donation for his 28-yr-old daughter. An MRT scan revealed two cysts in the right kidney. Right-sided donor nephrectomy and subsequent transplantation was performed. The wall of the prominent cyst was partially excised prior to transplantation. Histology revealed a high-grade renal clear cell carcinoma 10 d after transplantation. Following careful evaluation the recipient underwent partial nephrectomy. Immunosuppression was switched to rapamune. The graft function remained stable. Donor and recipient are without evidence of tumor recurrence 1 yr after transplantation. Our policy to obtain the kidney presenting anatomical variations proved to be beneficial for the donor. In case of transmission of cancer partial resection preserving graft function might be justified.
癌症传播是器官移植中的致命风险。我们报告一例在来自活体供者的肾脏中偶然发现肾癌的病例。一名56岁的父亲接受评估，准备为其28岁的女儿捐献肾脏。磁共振成像（MRT）扫描显示右肾有两个囊肿。进行了右侧供肾切除术及随后的移植手术。在移植前，突出囊肿的囊壁被部分切除。移植后10天，组织学检查显示为高级别肾透明细胞癌。经过仔细评估，受者接受了部分肾切除术。免疫抑制改为雷帕霉素。移植肾功能保持稳定。移植后1年，供者和受者均无肿瘤复发迹象。我们获取存在解剖变异肾脏的策略被证明对供者有益。在癌症传播的情况下，保留移植肾功能的部分切除术可能是合理的。
