Ghafari A
Departments of Nephrology and Renal Transplantation, Urmia University of Medical Sciences, Emam Khomini Hospital, Ershad Street, Uromieh, West Azarbaijan 571317785, Iran.
Transplant Proc. 2007 Jun;39(5):1660-1. doi: 10.1016/j.transproceed.2007.02.089.
Transmission of cancer is a serious risk in organ transplantation. We present a case of renal cell carcinoma (RCC) in a kidney obtained from a living donor. A 48-year-old mother was evaluated for donation to her 12-year-old daughter. Donor renal ultrasound, intravenous pyelography, and angiography were normal. A 5 x 5 mm nodule found on the surface of the kidney during harvesting was totally excised before transplantation. The histology revealed RCC with free margins at 2 weeks after transplantation. The immunosuppressive drugs consisted of cyclosporine, mycophenolate mofetil, and prednisolone. The graft function remained stable. Donor and recipient are without evidence of tumor recurrence at 15 months after transplantation. This experience indicated that donor kidneys with small, incidental RCC may be managed with excision and transplantation, without tumor recurrence in recipients who are informed of the potential risks of recurrence and metastases.
癌症传播在器官移植中是一个严重风险。我们报告一例来自活体供者的肾中发生肾细胞癌（RCC）的病例。一名48岁母亲接受评估，准备将肾脏捐给她12岁的女儿。供者肾脏超声、静脉肾盂造影和血管造影均正常。摘取肾脏时在肾表面发现一个5×5毫米的结节，在移植前将其完整切除。组织学检查显示移植后2周时切除边缘无癌细胞的肾细胞癌。免疫抑制药物包括环孢素、霉酚酸酯和泼尼松龙。移植肾的功能保持稳定。移植后15个月，供者和受者均无肿瘤复发迹象。这一经验表明，对于偶然发现的小肾细胞癌供肾，可通过切除和移植进行处理，对于被告知有复发和转移潜在风险的受者，不会出现肿瘤复发。
