Gruttadauria Salvatore, Cintorino Davide, Musumeci Alfredo, Arcadipane Antonio, Burgio Gaetano, Clarizia Sergio, Piazza Tommaso, Spada Marco, Verzaro Roberto, Marsh James W, Marcos Amadeo, Gridelli Bruno
Department of Abdominal Transplantation, Institute Mediterraneo per i Trapianti e Terapie ad Alta Specializzasione, Univeristy of Pittsburgh Medical Center European Medical Division, Palermo, Italy.
Clin Transplant. 2006 Mar-Apr;20(2):159-62. doi: 10.1111/j.1399-0012.2005.00458.x.
The aim of this study was to determine the impact of two reperfusion techniques on the peri-operative hemodynamic changes and early post-operative graft function of adult patients undergoing orthotopic liver transplantation.
From June 2003 to May 2004, 50 consecutive liver transplants were performed and divided into two groups: group A, 25 patients, portal vein flush with 500 cm(3) of Ringer's lactate without vena caval venting. Group B, 25 patients, vena caval venting with no portal vein flush. Donor and recipient characteristics were similar in both groups. Sixty-four different parameters were analyzed, and Pearson's chi(2) test and t-test were used for statistical analysis, p<or=0.05.
One patient (4%) in group B experienced a post-reperfusion syndrome (PRS). Pearson's chi(2) test found a significant relationship between the analyzed parameters and the two different reperfusion techniques for 10 parameters (t-test analysis showed a significant difference between the two groups in favor of group A).
In our transplant center, portal vein flush without vena caval venting provided a lower incidence of hemodynamic changes in the peri-operative period after liver transplantation and earlier recovery of the graft function.
本研究的目的是确定两种再灌注技术对接受原位肝移植的成年患者围手术期血流动力学变化和术后早期移植物功能的影响。
2003年6月至2004年5月，连续进行了50例肝移植手术，并分为两组：A组，25例患者，门静脉用500立方厘米乳酸林格液冲洗，不进行腔静脉排气。B组，25例患者，进行腔静脉排气，不进行门静脉冲洗。两组供体和受体特征相似。分析了64个不同参数，采用Pearson卡方检验和t检验进行统计学分析，p≤0.05。
B组有1例患者（4%）发生再灌注综合征（PRS）。Pearson卡方检验发现，对于10个参数，分析参数与两种不同再灌注技术之间存在显著关系（t检验分析显示两组之间存在显著差异，A组更具优势）。
在我们的移植中心，不进行腔静脉排气的门静脉冲洗在肝移植术后围手术期血流动力学变化发生率较低，移植物功能恢复较早。
