Diabate A, Chandre F, Rowland M, N'guessan R, Duchon S, Dabire K R, Hougard J-M
Institut de Recherche en Sciences de la Santé, Centre Muraz, Bobo-Dioulasso, Burkina Faso.
Trop Med Int Health. 2006 May;11(5):597-603. doi: 10.1111/j.1365-3156.2006.01605.x.
To evaluate the efficacy of permethrin-treated plastic sheeting (ITPS) applied as a lining to the ceiling or walls of rooms against pyrethroid-susceptible and pyrethroid-resistant Anopheles gambiae.
Overnight tests were carried out in veranda-trap experimental huts in Vallée du Kou, where two molecular forms of A. gambiae, S and M, occur. The S form is mostly pyrethroid resistant due to the kdr mechanism, and the M form is mostly kdr susceptible. A variety of ITPS covered surfaces were tested, ranging from ceiling only to all walls plus ceiling covered.
ITPS had a major effect on the mortality of mosquitoes, the proportion killed being dependent upon the surface area covered. Homozygotes for kdr resistance showed lower rates of mortality than did heterozygotes or homozygotes for susceptibility. Deterred entry of mosquitoes and inhibition of blood feeding were also correlated with surface area covered. The mode of action and efficacy of ITPS seems to bear closer resemblance to that induced by indoor residual spraying (IRS) than to that induced by insecticide-treated nets.
ITPS might be conceived as being equivalent to long-lasting or permanent IRS but without some of the operational constraints normally associated with spraying. High coverage of ITPS could potentially have a mass population effect on mosquitoes and give rise to long-term community protection against malaria. A phase III trial is justified to assess the acceptability of ITPS and its efficacy against malaria.
评估用氯菊酯处理的塑料薄膜（ITPS）作为房间天花板或墙壁内衬对拟除虫菊酯敏感和抗拟除虫菊酯的冈比亚按蚊的效果。
在库山谷的阳台诱捕实验小屋中进行过夜试验，那里存在冈比亚按蚊的两种分子形式，即S型和M型。S型由于kdr机制大多对拟除虫菊酯具有抗性，而M型大多对kdr敏感。测试了多种覆盖有ITPS的表面，范围从仅天花板到所有墙壁加天花板都覆盖。
ITPS对蚊子死亡率有重大影响，被杀死的比例取决于覆盖的表面积。kdr抗性纯合子的死亡率低于杂合子或敏感纯合子。蚊子进入受阻和取食受抑制也与覆盖的表面积相关。ITPS的作用方式和效果似乎与室内滞留喷洒（IRS）引起的更相似，而不是与经杀虫剂处理的蚊帐引起的相似。
ITPS可被视为等同于长效或永久性IRS，但没有一些通常与喷洒相关的操作限制。ITPS的高覆盖率可能对蚊子产生群体效应，并为社区提供长期的疟疾防护。进行III期试验以评估ITPS的可接受性及其对疟疾的疗效是合理的。
