Courtin David, Jamonneau Vincent, Mathieu Jean-François, Koffi Mathurin, Milet Jacqueline, Yeminanga Claude Sese, Kumeso Victor Kande Betu, Cuny Gérard, Bilengue Constantin Miaka Mia, Garcia André
Institut de Recherche pour le Développement, Santé de la mère et de l'enfant en milieu tropical, Paris, France.
Trop Med Int Health. 2006 May;11(5):647-53. doi: 10.1111/j.1365-3156.2006.01612.x.
Immunological studies suggest that human African trypanosomiasis (HAT) is associated with inflammatory responses. A better understanding of the complex cytokine interactions regulating HAT infections is essential to elucidate the mechanisms of generalized immunosuppression.
We determined levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma protein levels in plasma samples from three groups of individuals from the Democratic Republic of Congo: (i) HAT cases; (ii) seropositive individuals for whom parasite detection was negative and (ii) controls.
Plasma levels of six cytokines were significantly higher in HAT cases than in both controls (P<0.003) and seropositive individuals (P<0.016). IL-2 and IL-10 concentrations were significantly lower (P<0.02) in the seropositive group than in the control one.
Human African trypanosomiasis leads to the development of strong cytokine responses, indicating the potential involvement of IL-2 and IL-10 in the phenomenon of seropositivity without parasitological confirmation. This strongly suggests the involvement of immunity in this particular aspect of HAT epidemiology.
免疫学研究表明，人类非洲锥虫病（HAT）与炎症反应有关。更好地理解调节HAT感染的复杂细胞因子相互作用对于阐明全身免疫抑制机制至关重要。
我们测定了来自刚果民主共和国三组个体血浆样本中白细胞介素（IL）-2、IL-4、IL-6、IL-10、肿瘤坏死因子（TNF）-α和干扰素（IFN）-γ的蛋白水平：（i）HAT病例；（ii）寄生虫检测为阴性的血清阳性个体；（iii）对照组。
HAT病例中六种细胞因子的血浆水平显著高于对照组（P<0.003）和血清阳性个体（P<0.016）。血清阳性组中IL-2和IL-10浓度显著低于对照组（P<0.02）。
人类非洲锥虫病导致强烈的细胞因子反应，表明IL-2和IL-10可能参与了血清阳性但未经寄生虫学确认的现象。这强烈提示免疫在HAT流行病学的这一特定方面发挥作用。
