黄褐斑和获得性皮肤黑素沉着症的重复治疗方案。
Repeated treatment protocols for melasma and acquired dermal melanocytosis.
作者信息
Yoshimura Kotaro, Sato Katsujiro, Aiba-Kojima Emiko, Matsumoto Daisuke, Machino Chiaki, Nagase Takashi, Gonda Koichi, Koshima Isao
机构信息
Department of Plastic Surgery, University of Tokyo, School of Medicine, Tokyo, Japan.
出版信息
Dermatol Surg. 2006 Mar;32(3):365-71. doi: 10.1111/j.1524-4725.2006.032074.x.
BACKGROUND AND OBJECTIVE
Melasma and acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) are both seen most commonly symmetrically on the face of women with darker skin and are also known as difficult conditions to treat.
METHODS
Our topical bleaching protocol with 0.1 to 0.4% tretinoin gel and 5% hydroquinone was performed repeatedly (1-3 times) for melasma (n=163), and a combination treatment with topical bleaching and Q-switched ruby (QSR) laser was performed repeatedly (1-3 times) for ADM (n=62).
RESULTS
There is a significant correlation between clinical results (clearance of pigmentation) and the number of sessions in both melasma (p=.019) and ADM (p<.0001).
CONCLUSION
The repeated treatment protocol for melasma and ADM showed successful clinical results compared with conventional ones, and they may be applied to other pigment conditions. It may be better that epidermal and dermal pigmentations are treated separately, especially in dark-skinned people who are more likely to suffer postinflammatory hyperpigmentation after inflammation-inducing therapies.
背景与目的
黄褐斑和获得性真皮黑素细胞增多症（ADM；获得性双侧太田痣样斑）最常见于皮肤较黑的女性面部，且对称分布，也是已知难以治疗的病症。
方法
对163例黄褐斑患者反复（1 - 3次）采用含0.1%至0.4%维甲酸凝胶和5%氢醌的局部漂白方案进行治疗，对62例ADM患者反复（1 - 3次）采用局部漂白与Q开关红宝石（QSR）激光联合治疗。
结果
在黄褐斑（p = 0.019）和ADM（p < 0.0001）中，临床结果（色素沉着清除情况）与治疗次数之间均存在显著相关性。
结论
与传统方案相比，黄褐斑和ADM的重复治疗方案显示出成功的临床效果，且可应用于其他色素沉着病症。分别治疗表皮和真皮色素沉着可能更好，尤其是在深色皮肤人群中，他们在诱导炎症的治疗后更易出现炎症后色素沉着。
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