Lew Bark-lynn, Cho Yunhi, Lee Mu-hyoung
Department of Dermatology, College of Medicine, Kyunghee University, Seoul, Korea.
Dermatol Surg. 2006 Mar;32(3):376-9. doi: 10.1111/j.1524-4725.2006.32076.x.
Microdermabrasion has become a popular method for superficial resurfacing of the epidermis. Despite the popularity of this technique, few studies have examined changes in the levels of lipids (especially ceramide) in the stratum corneum following microdermabrasion.
To assess and analyze changes in the ceramide level in the stratum corneum during the course of serial aluminum oxide microdermabrasion.
Eleven healthy volunteers were enrolled in this study. Each participant underwent microdermabrasion once a week for 5 weeks. Following each procedure, the ceramide level in the resulting epidermal scales was measured.
A statistically significant increase in the ceramide level in the stratum corneum was observed following the first and second microdermabrasion sessions. After the third and fourth sessions, the ceramide level returned to baseline.
The results suggest that microdermabrasion alters the epidermal ceramide level. These findings provide the first evidence of alterations in the lipid barrier following microdermabrasion.
微晶磨皮术已成为一种用于表皮浅层重建的常用方法。尽管这项技术很受欢迎，但很少有研究探讨微晶磨皮术后角质层中脂质（尤其是神经酰胺）水平的变化。
评估并分析连续进行氧化铝微晶磨皮术过程中角质层神经酰胺水平的变化。
11名健康志愿者参与了本研究。每位参与者每周接受一次微晶磨皮术，共进行5周。每次术后，测量所得表皮鳞屑中的神经酰胺水平。
在第一次和第二次微晶磨皮术后，观察到角质层中神经酰胺水平有统计学意义的升高。在第三次和第四次术后，神经酰胺水平恢复到基线。
结果表明微晶磨皮术会改变表皮神经酰胺水平。这些发现为微晶磨皮术后脂质屏障的改变提供了首个证据。
