Campbell L J, Van der Weyden M B
Department of Hematology, Alfred Hospital, Prahran, Victoria, Australia.
Pathology. 1991 Jul;23(3):198-201. doi: 10.3109/00313029109063566.
The peripheral blood hematological and biochemical parameters in 60 patients with marrow involvement with carcinoma are described. In all patients the hematologic findings were of anemia (46%), thrombocytopenia (36%), leukocytosis (28%) and leukoerythroblastosis (22%). Elevated serum lactate dehydrogenase (sLDH) and alkaline phosphatase (sALP) occurred in 78% of patients and hypercalcemia in 28% and these abnormal biochemical parameters occurred more frequently with marrow fibrosis. In patients with small cell carcinoma of lung (SCCL) the sLDH was normal in 24% and sALP in 32% and abnormal hematological findings or a raised sLDH occurred more frequently with liver involvement. Bone scan was positive in 49% of patients and the hematological and biochemical parameters in these patients were similar to those of patients with a normal scan. Ten percent of patients with SCCL and marrow involvement had both a normal sLDH and bone scan.
描述了60例癌累及骨髓患者的外周血血液学和生化参数。所有患者的血液学表现为贫血（46%）、血小板减少（36%）、白细胞增多（28%）和成粒-幼红细胞血象（22%）。78%的患者血清乳酸脱氢酶（sLDH）和碱性磷酸酶（sALP）升高，28%的患者血钙过高，这些异常生化参数在骨髓纤维化患者中出现得更频繁。在肺小细胞癌（SCCL）患者中，24%的患者sLDH正常，32%的患者sALP正常，肝脏受累时异常血液学表现或sLDH升高更为常见。49%的患者骨扫描呈阳性，这些患者的血液学和生化参数与扫描正常的患者相似。10%的SCCL伴骨髓受累患者sLDH和骨扫描均正常。
