Levitan N, Byrne R E, Bromer R H, Faling L J, Caslowitz P, Pattern D H, Hong W K
Cancer. 1985 Aug 1;56(3):652-4. doi: 10.1002/1097-0142(19850801)56:3<652::aid-cncr2820560336>3.0.co;2-g.
The charts of 112 patients with small cell lung cancer were reviewed in a retrospective fashion in order to define the role of the radionuclide bone scan and bone marrow biopsy in the staging of this disease. Both a radionuclide bone scan and bone marrow biopsy were performed on all patients at the time of diagnosis. Sixty-one percent of patients had a negative bone scan and negative biopsy; 22% had a positive bone scan and negative biopsy; 8% had a negative scan and positive biopsy; and 9% had a positive scan and positive biopsy. In 21 of the 44 patients with osseous involvement, no other focus of distant metastasis was found. The bone scan showed greater than or equal to 3 areas of increased uptake in 15 patients, 2 areas of increased uptake in 13 patients, and 1 area in 7 patients. The number of patients with bone marrow biopsy results positive for tumor in these 3 groups were 5, 3, and 2, respectively. Our study shows a lack of correlation between bone scan and bone marrow biopsy results. The bone scan and bone marrow biopsy identify independent patterns of osseous metastasis. Both procedures should be performed in the evaluation of patients with small cell lung cancer.
为明确放射性核素骨扫描和骨髓活检在小细胞肺癌分期中的作用，我们对112例小细胞肺癌患者的病历进行了回顾性研究。所有患者在诊断时均接受了放射性核素骨扫描和骨髓活检。61%的患者骨扫描和活检结果均为阴性；22%的患者骨扫描阳性但活检阴性；8%的患者扫描阴性但活检阳性；9%的患者扫描和活检均为阳性。在44例有骨转移的患者中，有21例未发现其他远处转移灶。骨扫描显示，15例患者有3个或更多摄取增加区域，13例患者有2个摄取增加区域，7例患者有1个摄取增加区域。这3组中骨髓活检结果为肿瘤阳性的患者数量分别为5例、3例和2例。我们的研究表明，骨扫描和骨髓活检结果之间缺乏相关性。骨扫描和骨髓活检可识别独立的骨转移模式。在评估小细胞肺癌患者时，这两种检查都应进行。
