FAEV方案治疗高危耐药性妊娠滋养细胞肿瘤的疗效
[Efficacy of FAEV regimen in treatment of high-risk drug-resistant gestational trophoblastic tumor].
作者信息
Wan Xi-run, Xiang Yang, Yang Xiu-yu, Wu Yu, Liu Ning, Chen Ling, Dong Ruo-fan
机构信息
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2006 Feb;41(2):88-90.
OBJECTIVE
To evaluate the efficacy of floxuridine, actinomycin D, etoposide, vincristine (FAEV) regimen in treatment of high-risk drug-resistant gestational trophoblastic tumor (GTT).
METHODS
From October 2001 to May 2004, 11 cases of high-risk drug-resistant GTT were treated with FAEV regimen. The International Federation of Gynecology and Obstetrics (FIGO) prognosis score (2000) was 7 to 13 (median 9). All patients were referred to Peking Union Medical College Hospital because of failure of chemotherapy previously. After the FAEV treatment, they were followed up for 15 to 42 months.
RESULTS
Seven cases (64%, 7/11) were cured by FAEV regimen. The median treatment course for serum human chorionic gonadotropin reaching normal level was 3. Four cases (36%, 4/11) showed drug-resistant to FAEV regimen. The major side effect of FAEV regimen was myelosuppression. Granulocyte colony stimulating factor support was needed after 98% (63/64) of the courses.
CONCLUSION
For those high-risk drug-resistant GTT cases, FAEV regimen could be considered as an effective choice of treatment.
目的
评估氟尿苷、放线菌素D、依托泊苷、长春新碱（FAEV）方案治疗高危耐药性妊娠滋养细胞肿瘤（GTT）的疗效。
方法
2001年10月至2004年5月，11例高危耐药性GTT患者采用FAEV方案治疗。国际妇产科联合会（FIGO）预后评分（2000年）为7至13分（中位数9分）。所有患者此前因化疗失败转诊至北京协和医院。接受FAEV治疗后，对其进行了15至42个月的随访。
结果
7例（64%，7/11）患者通过FAEV方案治愈。血清人绒毛膜促性腺激素达到正常水平的中位疗程为3个疗程。4例（36%，4/11）患者对FAEV方案耐药。FAEV方案的主要副作用是骨髓抑制。98%（63/64）的疗程后需要粒细胞集落刺激因子支持。
结论
对于那些高危耐药性GTT病例，FAEV方案可被视为一种有效的治疗选择。
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