重新审视机体自身抗体的处理
Processing body autoantibodies reconsidered.
作者信息
Bloch Donald B, Gulick Tod, Bloch Kenneth D, Yang Wei-Hong
出版信息
RNA. 2006 May;12(5):707-9. doi: 10.1261/rna.17406.
Abstract
Processing bodies (P-bodies) are cellular structures that have critical roles in mRNA degradation and post-transcriptional gene silencing. Some patients with autoimmune disease have high titer antibodies directed against P-bodies, and certain sera have been used as markers for the GW182 component of these structures. This study shows that available reference sera are unreliable markers for GW182 because the sera contain antibodies directed against Ge-1, a second P-body autoantigen.
摘要
加工小体（P小体）是细胞结构，在mRNA降解和转录后基因沉默中起关键作用。一些自身免疫性疾病患者具有针对P小体的高滴度抗体，某些血清已被用作这些结构中GW182成分的标志物。本研究表明，现有的参考血清作为GW182的标志物并不可靠，因为这些血清中含有针对Ge-1（另一种P小体自身抗原）的抗体。
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