Lyoo In Kyoon, Hwang Jaeuk, Sim Minyoung, Dunn Brian J, Renshaw Perry F
Department of Psychiatry, Seoul National University, South Korea, Seoul, South Korea.
CNS Spectr. 2006 Apr;11(4):269-80. doi: 10.1017/s1092852900020770.
This article reviews the current state of magnetic resonance imaging techniques as applied to bipolar disorder. Addressed are conventional methods of structural neuroimaging and recently developed techniques. This latter group comprises volumetric analysis, voxel-based morphometry, the assessment of T2 white matter hyperintensities, shape analysis, cortical surface-based analysis, and diffusion tensor imaging. Structural analysis methods used in magnetic resonance imaging develop exponentially, and now present opportunities to identify disease-specific neuroanatomic alterations. Greater acuity and complementarity in measuring these alterations has led to the generation of further hypotheses regarding the pathophysiology of bipolar disorder. Included in the summary of findings is consideration of a resulting neuroanatomic model. Integrative issues and future directions in this relatively young field, including multi-modal approaches enabling us to produce more comprehensive results, are discussed.
本文综述了应用于双相情感障碍的磁共振成像技术的现状。文中讨论了传统的结构神经成像方法以及最近开发的技术。后一组技术包括体积分析、基于体素的形态测量、T2白质高信号评估、形状分析、基于皮质表面的分析以及扩散张量成像。磁共振成像中使用的结构分析方法呈指数级发展，现在为识别疾病特异性神经解剖学改变提供了机会。在测量这些改变方面更高的敏锐度和互补性导致了关于双相情感障碍病理生理学的进一步假设的产生。研究结果总结中包括对由此产生的神经解剖学模型的考量。本文还讨论了这个相对年轻领域中的整合问题和未来方向，包括使我们能够产生更全面结果的多模态方法。
