Chermesh Irit, Tamir Ada, Suissa Alain, Eliakim Rami
Department of Gastroenterology, Rambam Medical Center, P.O.B. 9602, Technion-Israel Institute of Technology, Haifa, Israel.
Dig Dis Sci. 2006 May;51(5):942-5. doi: 10.1007/s10620-005-9036-6. Epub 2006 Apr 27.
Our purpose was to compare the absorption of iron bisglycinate and ferrous calcium citrate in volunteers using an oral iron tolerance test. Twenty volunteers, 10 healthy controls and 10 with stable Crohn's disease, agreed to participate in the study. All were given 50 mg of elemental iron as iron bisglycinate or ferrous calcium citrate. Serum iron levels were monitored for 4 hr. After a week, each received the other regimen. Using the area under the curve as indicator, the oral iron absorption test revealed that absorption of iron post-ingestion of ferrous calcium citrate was better than after ingestion of iron bisglycinate for the group as a whole (P < 0.03). Volunteers with Crohn's disease absorbed ferrous calcium citrate better than iron bisglycinate (P=0.005). No difference was noted in the absorption of either preparation by healthy volunteers. Ferrus calcium citrate is apparently more effective than iron bisglycinate in patients with Crohn's disease.
我们的目的是通过口服铁耐量试验比较甘氨酸亚铁和柠檬酸亚铁钙在志愿者体内的吸收情况。20名志愿者，10名健康对照者和10名患有稳定克罗恩病的患者，同意参与该研究。所有人均服用50毫克元素铁，形式为甘氨酸亚铁或柠檬酸亚铁钙。监测血清铁水平4小时。一周后，每人接受另一种方案。以曲线下面积为指标，口服铁吸收试验显示，总体而言，柠檬酸亚铁钙摄入后铁的吸收优于甘氨酸亚铁摄入后（P < 0.03）。患有克罗恩病的志愿者对柠檬酸亚铁钙的吸收优于甘氨酸亚铁（P = 0.005）。健康志愿者对两种制剂的吸收未发现差异。在克罗恩病患者中，柠檬酸亚铁钙显然比甘氨酸亚铁更有效。
