Bovell-Benjamin A C, Viteri F E, Allen L H
Program in International Nutrition, the Department of Nutrition, University of California, Davis, CA 95616, USA.
Am J Clin Nutr. 2000 Jun;71(6):1563-9. doi: 10.1093/ajcn/71.6.1563.
There is a need to determine whether iron absorption from iron amino acid chelates is protected from inhibition by dietary phytate and regulated normally by iron status.
The objective of this study was to compare iron absorption from ferrous sulfate, ferrous bisglycinate, and ferric trisglycinate in whole-maize meal; to determine whether iron from ferrous bisglycinate and ferrous sulfate exchanges in the intestinal pool; and to assess iron absorption from ferrous bisglycinate and ferric trisglycinate over a range of iron statuses.
In study 1A, 10 iron-sufficient men consumed ferrous sulfate-fortified whole-maize meal porridge equilibrated with (59)Fe-sulfate on day 1 and (55)Fe-bisglycinate on day 2. In study 1B, these volunteers consumed ferrous sulfate-fortified porridge equilibrated with (59)Fe-sulfate and (55)Fe-bisglycinate simultaneously. In studies 2A and 2B, iron absorption from 3 mg Fe as (59)Fe-ascorbate, (55)Fe-bisglycinate, or (59)Fe-trisglycinate in water and in porridge was compared in 23 subjects with a range of iron statuses. Iron absorption was determined from blood radioactivity on day 16.
In study 1A, geometric mean iron absorption from ferrous bisglycinate was 6.0% (range: 2.6-13.6%), 4 times higher than that from ferrous sulfate (1. 7%; range: 1.0-3.3%; P < 0.05). In study 1B, absorption from neither source was different from that in study 1A. In studies 2A and 2B, absorption from all sources was strongly inversely related to serum ferritin, with geometric means of 32.5% (iron ascorbate), 9.1% (bisglycinate), and 15.3% (trisglycinate). Iron from ferric trisglycinate was poorly absorbed (2.3%; range: 0.5-9.2%) from maize.
In whole-maize meal, iron from ferrous bisglycinate is better absorbed than is iron from ferrous sulfate and does not exchange with iron from maize or ferrous sulfate in the intestinal pool. Absorption of iron from bisglycinate and trisglycinate is regulated normally by iron status.
有必要确定从氨基酸螯合铁中吸收的铁是否能免受膳食植酸盐的抑制，以及是否能正常地受铁状态调节。
本研究的目的是比较硫酸亚铁、甘氨酸亚铁和三甘氨酸铁在全玉米粉中的铁吸收情况；确定甘氨酸亚铁和硫酸亚铁中的铁在肠道池中是否会交换；并评估在一系列铁状态下甘氨酸亚铁和三甘氨酸铁的铁吸收情况。
在研究1A中，10名铁充足的男性在第1天食用用（59）Fe-硫酸盐平衡的硫酸亚铁强化全玉米粉粥，在第2天食用用（55）Fe-甘氨酸螯合物平衡的粥。在研究1B中，这些志愿者同时食用用（59）Fe-硫酸盐和（55）Fe-甘氨酸螯合物平衡的硫酸亚铁强化粥。在研究2A和2B中，比较了23名处于不同铁状态的受试者对3毫克以（59）Fe-抗坏血酸盐、（55）Fe-甘氨酸螯合物或（59）Fe-三甘氨酸形式存在的铁在水中和粥中的吸收情况。在第16天根据血液放射性测定铁吸收情况。
在研究1A中，甘氨酸亚铁的几何平均铁吸收率为6.0%（范围：2.6%-13.6%），是硫酸亚铁（1.7%；范围：1.0%-3.3%；P<0.05）的4倍。在研究1B中，两种来源的吸收率与研究1A中的无差异。在研究2A和2B中，所有来源的铁吸收均与血清铁蛋白呈强烈负相关，几何平均值分别为32.5%（抗坏血酸铁）、9.1%（甘氨酸亚铁）和15.3%（三甘氨酸铁）。从玉米中吸收的三甘氨酸铁很差（2.3%；范围：0.5%-9.2%）。
在全玉米粉中，甘氨酸亚铁中的铁比硫酸亚铁中的铁吸收更好，并且在肠道池中不与玉米或硫酸亚铁中的铁交换。甘氨酸亚铁和三甘氨酸铁的铁吸收正常地受铁状态调节。
