Lykissa E D, Maharaj S V M
ExperTox, Inc., Deer Park, Texas 77536, USA.
Anal Chem. 2006 May 1;78(9):2925-33. doi: 10.1021/ac0514016.
Ion chromatography-inductively coupled plasma-mass spectrometry was used to determine the total platinum concentration and platinum oxidation states in samples from women exposed to silicone and saline breast implants. Samples included the following: whole blood, urine, hair, nails, sweat, brain tissue, breast milk, and explants. Mean Pt concentration in samples from women exposed to silicone breast implants were as follows: whole blood, 568.1 +/- 74.77 pmol/L (n = 9); urine, 1.77 +/- 0.847 mug/g of creatinine (n = 10); hair, 2.13 +/- 2.984 ng/g (n = 9); nails, 0.88 +/- 0.335 ng/g (n = 9); sweat, 1.90 +/- 1.691 ng/g (n = 9); breast milk, 1.09 +/- 0.316 mug/L (n = 6). Pt in explanted silicone breast implant gel (n = 9) occurred mainly in the +2, +4, and +6 oxidation states. Pt in whole blood (n = 7) and breast milk samples (n = 6) from women exposed to silicone breast implants occurred mainly in the +2 and +4 oxidation states. Saline breast implant fluid (n = 2) did not contain detectable levels of Pt. This is the most comprehensive report, to date, to show that women exposed to silicone breast implants have Pt levels that exceed that of the general population, and the first report, to date, to document the various Pt oxidation states present in samples from women exposed to silicone breast implants.
采用离子色谱-电感耦合等离子体质谱法测定接触硅胶和盐水乳房植入物的女性样本中的总铂浓度和铂氧化态。样本包括以下几种：全血、尿液、头发、指甲、汗液、脑组织、母乳和植入物。接触硅胶乳房植入物的女性样本中的铂平均浓度如下：全血，568.1±74.77 pmol/L（n = 9）；尿液，1.77±0.847 μg/g肌酐（n = 10）；头发，2.13±2.984 ng/g（n = 9）；指甲，0.88±0.335 ng/g（n = 9）；汗液，1.90±1.691 ng/g（n = 9）；母乳，1.09±0.316 μg/L（n = 6）。取出的硅胶乳房植入物凝胶中的铂（n = 9）主要以+2、+4和+6氧化态存在。接触硅胶乳房植入物的女性的全血样本（n = 7）和母乳样本（n = 6）中的铂主要以+2和+4氧化态存在。盐水乳房植入物液体（n = 2）中未检测到铂。这是迄今为止最全面的报告，表明接触硅胶乳房植入物的女性的铂水平超过一般人群，也是迄今为止第一份记录接触硅胶乳房植入物的女性样本中存在的各种铂氧化态的报告。
