Zhou W
Chinese PLA General Hospital, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1991 Sep;20(3):184-6.
DNA content of paraffin-embedded tumour material from 110 patients with lung carcinoma was measured by means of flow cytometry. Aneuploidy was found in 78% of the patients. The mean DNA ploid, the percentage of hyperdiploidy and the percentage of multiploidy in small cell carcinoma and large cell carcinoma were higher than those obtained in squamous cell carcinoma and adenocarcinoma. These values were also higher in grade III squamous cell carcinoma and adenocarcinoma as compared with grade I and II squamous cell carcinoma, and adenocarcinoma. They were also higher in lung carcinoma with the primary tumor size greater than or equal to 3 cm than that less than 3 cm. The five-year survival rate and mid mean survival time of patients with hyperdiploidy were significantly lower than those of patients with diploidy and hypodiploidy. Conclusively, DNA content is considered closely related to the degree of malignancy of lung carcinoma and may be adapted as a reliable criterion in estimating the prognosis of lung carcinoma.
采用流式细胞术对110例肺癌患者石蜡包埋肿瘤组织的DNA含量进行了测定。78%的患者存在非整倍体。小细胞癌和大细胞癌的平均DNA倍体、超二倍体百分比和多倍体百分比高于鳞状细胞癌和腺癌。与I级和II级鳞状细胞癌及腺癌相比，III级鳞状细胞癌和腺癌的这些值也更高。原发性肿瘤大小大于或等于3 cm的肺癌患者的这些值也高于小于3 cm的患者。超二倍体患者的五年生存率和平均生存时间显著低于二倍体和亚二倍体患者。总之，DNA含量被认为与肺癌的恶性程度密切相关，可作为评估肺癌预后的可靠标准。
