Shiota T, Konishi T, Kosaba S, Mitsuoka A, Matsubara Y, Hatakenaka R, Funatsu T, Ikeda S, Matsumoto H, Ishigami F
Kyoto Katsura Hospital, Respiratory Center, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1990 Dec;38(12):2364-9.
The cellular DNA content of lung cancer were measured by flow cytometry on 223 paraffin-embedded specimens prepared from resected lung carcinomas. According to the histological type of lung cancer, the mean values for the DNA Index were 1.41 in adenocarcinoma, 1.39 in squamous cell carcinoma, 1.33 in large cell carcinoma and 1.84 in small cell carcinoma. The DNA Index of small cell carcinoma was thus slightly higher than that of the other histological types, without statistically significant difference. Of 223 lung carcinoma cases, 131 (59.1%) were DNA aneuploidy and 92 (40.9%) were DNA diploidy. DNA aneuploidy was found in 56.1% of adenocarcinomas, 59.5% of squamous cell carcinomas, 53.3% of large cell carcinomas and 100% of small cell carcinomas. According to the staging of the lung cancer, the mean values of the DNA Index were 1.40 in stage I, 1.46 in stage II, 1.36 in stage IIIA, 1.48 in stage IIIB and 1.48 in stage IV. No statistically significant differences were found among these stages. DNA aneuploidy was found in 57.1% of stage I, 57.9% of stage II, 54.7% of stage IIIA, 60.0% of stage IIIB and 75.0% of stage IV. The correlation of DNA content with survival were investigated in 94 cases with stage I non-small cell carcinoma which underwent absolute curative resection. Of 94 cases, the 5-year survival rate of 40 cases with DNA diploidy was 81.1% and a mean survival time 111 months, while this one of the remaining 54 with DNA aneuploidy was 58.4% and a mean survival time 80 months.(ABSTRACT TRUNCATED AT 250 WORDS)
采用流式细胞术对223例手术切除的肺癌石蜡包埋标本的细胞DNA含量进行了测定。根据肺癌的组织学类型，腺癌的DNA指数平均值为1.41，鳞状细胞癌为1.39，大细胞癌为1.33，小细胞癌为1.84。因此，小细胞癌的DNA指数略高于其他组织学类型，但差异无统计学意义。223例肺癌病例中，131例（59.1%）为DNA非整倍体，92例（40.9%）为DNA二倍体。腺癌中DNA非整倍体的比例为56.1%，鳞状细胞癌为59.5%，大细胞癌为53.3%，小细胞癌为100%。根据肺癌的分期，I期的DNA指数平均值为1.40，II期为1.46，IIIA期为1.36，IIIB期为1.48，IV期为1.48。各期之间差异无统计学意义。I期DNA非整倍体的比例为57.1%，II期为57.9%，IIIA期为54.7%，IIIB期为60.0%，IV期为75.0%。对94例行根治性切除的I期非小细胞肺癌患者的DNA含量与生存情况的相关性进行了研究。94例患者中，40例DNA二倍体患者的5年生存率为81.1%，平均生存时间为111个月，而其余54例DNA非整倍体患者的5年生存率为58.4%，平均生存时间为80个月。（摘要截断于250字）
