来自福建假卫矛茎的细胞毒性二氢沉香呋喃类倍半萜

Cytotoxic dihydroagarofuranoid sesquiterpenes from the stem of Microtropis fokienensis.

作者信息

Chen Jih-Jung, Chou Tsung-Hsien, Duh Chang-Yih, Chen Ih-Sheng

机构信息

Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan, Republic of China.

出版信息

J Nat Prod. 2006 Apr;69(4):685-8. doi: 10.1021/np050458k.

DOI:10.1021/np050458k

PMID:16643054

Abstract

Four dihydroagarofuran sesquiterpene polyesters (1-4) have been isolated from the stem of Microtropis fokienensis. The structures of these new compounds were determined through spectroscopic analyses. Compound 1, 2, 3, and 4 exhibited cytotoxicities (IC(50) values < 0.1 microg/mL) against P-388 and HT-29 cell lines in vitro.

摘要

从福建野桐茎中分离得到了四种二氢沉香呋喃倍半萜聚酯（1-4）。通过光谱分析确定了这些新化合物的结构。化合物1、2、3和4在体外对P-388和HT-29细胞系表现出细胞毒性（IC(50)值<0.1微克/毫升）。