福建假卫矛叶中的细胞毒性三萜类化合物。

Cytotoxic triterpenoids from the leaves of Microtropis fokienensis.

作者信息

Chen I-Hsiao, Chang Fang-Rong, Wu Chin-Chung, Chen Shu-Li, Hsieh Pei-Wen, Yen Hsin-Fu, Du Ying-Chi, Wu Yang-Chang

机构信息

Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.

出版信息

J Nat Prod. 2006 Nov;69(11):1543-6. doi: 10.1021/np060369n.

DOI:10.1021/np060369n

PMID:17125218

Abstract

Five new triterpenoids, microfokienoxanes A-D (1-4) and 3beta,28-dihydroxy-11alpha-methoxyurs-12-ene (5), were isolated and identified from the leaves of Microtropis fokienensis, along with nine known compounds. The structures of the new compounds were elucidated by spectroscopic methods. The compounds obtained in this investigation were evaluated against a small panel of human cancer cell lines for cytotoxicity. Only compounds 3 and 5 exhibited cytotoxicity (IC50 < or = 5 microg/mL) for one or more cell lines.

摘要

从福建野木瓜的叶子中分离并鉴定出5个新的三萜类化合物，即微福建乌苏烷型三萜A-D（1-4）和3β,28-二羟基-11α-甲氧基乌苏-12-烯（5），同时还分离出9个已知化合物。通过光谱方法阐明了新化合物的结构。对本次研究中获得的化合物针对一小部分人类癌细胞系进行了细胞毒性评估。只有化合物3和5对一种或多种细胞系表现出细胞毒性（IC50≤5μg/mL）。