• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The hydrolysis of phosphatidylinositol 4-phosphate in membranes of Xenopus laevis oocytes: characteristics of a phosphomonoesterase.

作者信息

Jacob G, Allende C C, Allende J E

机构信息

Departamento de Bioquímica, Facultad de Medicina, Universidad de Chile, Santiago.

出版信息

Comp Biochem Physiol B. 1991;100(4):809-16. doi: 10.1016/0305-0491(91)90295-o.

DOI:10.1016/0305-0491(91)90295-o
PMID:1664308
Abstract
  1. Phosphatidylinositol 4-phosphate (PtdIns4P) is degraded by isolated membranes from Xenopus laevis oocytes. 2. Incubation of [4-32P]PtdIns4P with membranes yields only radioactive inorganic phosphate, indicating the presence of a phosphomonoesterase. 3. Membranes hydrolyze Ptd[2-3H]Ins4P to produce mainly Ptd[2-3H]Ins in the lipid phase. In this incubation [3H]inositol and inositol monophosphate appear in the water phase. 4. Membrane incubations of Ptd[2-3H]Ins4P carried out in the presence of excess non-radioactive Ins(1,4)P2 allows the trapping of small amounts of [3H]Ins(1,4)P2. These results demonstrate the presence of a phospholipase C. 5. Testing several phosphorylated analogs, it is determined that fructose 1,6-bisphosphate and alpha-glycerophosphate are potent inhibitors of the oocyte PtdIns4P phosphomonoesterase.
摘要

相似文献

1
The hydrolysis of phosphatidylinositol 4-phosphate in membranes of Xenopus laevis oocytes: characteristics of a phosphomonoesterase.
Comp Biochem Physiol B. 1991;100(4):809-16. doi: 10.1016/0305-0491(91)90295-o.
2
Phosphoinositide hydrolysis by guanosine 5'-[gamma-thio]triphosphate-activated phospholipase C of turkey erythrocyte membranes.火鸡红细胞膜中由鸟苷5'-[γ-硫代]三磷酸激活的磷脂酶C引起的磷酸肌醇水解作用。
Biochem J. 1988 Jun 1;252(2):583-93. doi: 10.1042/bj2520583.
3
Characteristics of phospholipase C present in membranes of Xenopus laevis oocytes. Stimulation by phosphatidic acid.非洲爪蟾卵母细胞膜中存在的磷脂酶C的特性。磷脂酸的刺激作用。
Comp Biochem Physiol B. 1993 Dec;106(4):895-900. doi: 10.1016/0305-0491(93)90047-9.
4
Characterization of a phosphatidylinositol 4-phosphate-specific phosphomonoesterase in rat liver nuclear envelopes.大鼠肝细胞核膜中磷脂酰肌醇4-磷酸特异性磷酸单酯酶的特性研究
Arch Biochem Biophys. 1984 Dec;235(2):529-37. doi: 10.1016/0003-9861(84)90226-1.
5
The discovery of a 3-phosphomonoesterase that hydrolyzes phosphatidylinositol 3-phosphate in NIH 3T3 cells.
J Biol Chem. 1989 Nov 25;264(33):19911-5.
6
Ca2+ regulation of 1-(3-sn-phosphatidyl)-1D-myo-inositol 4-phosphate formation and hydrolysis on sarcoplasmic-reticular Ca2+-transport ATPase. A new principle of phospholipid turnover regulation.肌浆网Ca2+转运ATP酶上Ca2+对1-(3-sn-磷脂酰)-1D-肌醇4-磷酸形成与水解的调节。磷脂周转调节的新原理。
Biochem J. 1987 Nov 1;247(3):579-87. doi: 10.1042/bj2470579.
7
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate.两种可水解磷脂酰肌醇3-磷酸和肌醇1,3-二磷酸的3-磷酸酶的分离与鉴定。
J Biol Chem. 1991 Sep 25;266(27):18378-86.
8
Metabolism of the biologically active inositol phosphates Ins(1,4,5)P3 and Ins(1,3,4,5)P4 by ovarian follicles of Xenopus laevis.非洲爪蟾卵巢卵泡对生物活性肌醇磷酸酯Ins(1,4,5)P3和Ins(1,3,4,5)P4的代谢
Biochem J. 1990 May 15;268(1):141-5. doi: 10.1042/bj2680141.
9
Inositol phospholipid hydrolysis by rat sciatic nerve phospholipase C.大鼠坐骨神经磷脂酶C对肌醇磷脂的水解作用
J Neurochem. 1987 Dec;49(6):1878-87. doi: 10.1111/j.1471-4159.1987.tb02450.x.
10
Studies of endogenous polyphosphoinositide hydrolysis in human platelet membranes. Evidence that polyphosphoinositides remain inaccessible to phosphodiesterase in the native membrane.人血小板膜内源性多磷酸肌醇水解的研究。多磷酸肌醇在天然膜中对磷酸二酯酶仍不可接近的证据。
Biochim Biophys Acta. 1986 Feb 12;875(2):147-56. doi: 10.1016/0005-2760(86)90163-3.