丙型肝炎病毒感染患者在接受干扰素-α治疗期间出现的与自身免疫并发症相关的皮肤、肺部和肝脏结节病。

Cutaneous, pulmonary and hepatic sarcoidosis associated with autoimmune complications during interferon-alpha treatment for hepatitis C virus infection.

作者信息

Akay B N, Ekmekci P, Sanli H, Celik G, Bozdayi M

机构信息

Department of Dermatology, Ankara University School of Medicine, Ankara, Turkey.

出版信息

J Eur Acad Dermatol Venereol. 2006 Apr;20(4):442-5. doi: 10.1111/j.1468-3083.2006.01450.x.

DOI:10.1111/j.1468-3083.2006.01450.x

PMID:16643145

Abstract

A patient with hepatitis C virus (HCV) infection was diagnosed with cutaneous, pulmonary and hepatic sarcoidosis following interferon alpha therapy. There are only a few cases of sarcoidosis associated with this treatment. This is the first case who not only developed sarcoidosis, but also autoimmune hypothyroidism and thrombocytopenia during interferon alpha therapy due to the immunomodulatory effects of the drug.

摘要

一名丙型肝炎病毒（HCV）感染患者在接受α干扰素治疗后被诊断出患有皮肤、肺部和肝脏结节病。与这种治疗相关的结节病病例很少。这是首例不仅在α干扰素治疗期间因药物的免疫调节作用而发生结节病，还出现自身免疫性甲状腺功能减退和血小板减少症的病例。