Laube S, Shah F, Marsden J
SpR in Dermatology, Skin Oncology Service, University Hospital Birmingham, Raddlebarn Road, Selly Oak, Birmingham, UK.
Eur J Cancer Care (Engl). 2006 May;15(2):194-8. doi: 10.1111/j.1365-2354.2005.00632.x.
We report two patients with lymphomatoid papulosis (LyP), who were initially diagnosed as systemic T-cell lymphoma. The patients presented with recurrent self-healing cutaneous lesions and skin biopsies showed a lymphocytic infiltrate with malignant features. Clinico-pathological correlation of findings was not performed and results of staging investigations were misinterpreted. Consequently, both patients were unnecessarily treated with multi-agent chemotherapy, radiotherapy and stem cell/bone marrow transplants and sustained long-term adverse effects. The clinical and histological features of LyP are described and appropriate management discussed in detail. Factors leading to the unnecessary treatment of both patients are examined and several learning points highlighted such as the importance of a multidisciplinary approach.
我们报告了两名淋巴瘤样丘疹病（LyP）患者，他们最初被诊断为系统性T细胞淋巴瘤。患者表现为反复自愈的皮肤病变，皮肤活检显示有具有恶性特征的淋巴细胞浸润。未进行检查结果的临床病理相关性分析，分期检查结果也被错误解读。因此，两名患者均接受了不必要的多药化疗、放疗以及干细胞/骨髓移植，并遭受了长期的不良反应。本文描述了LyP的临床和组织学特征，并详细讨论了适当的治疗方法。分析了导致两名患者接受不必要治疗的因素，并强调了几个经验教训，如多学科方法的重要性。
