Christensen H K, Thomsen K, Vejlsgaard G L
Dermatological Department, Rigshospitalet, Copenhagen, Denmark.
Semin Dermatol. 1994 Sep;13(3):197-201.
Forty-one patients with lymphomatoid papulosis have been followed from 1 to 22 years (mean 11.4 years, median 10 years). Six patients developed malignant lymphoma, 3 cutaneous T-cell lymphoma, 2 Ki-1 large cell lymphoma, and 1 Hodgkin's disease. A clinical malignant presentation combined with the finding of aneuploidy in skin lesions seem to be indications of a malignant potential. Treatment with methotrexate in low dosage is an efficient treatment of lymphomatoid papulosis and probably diminishes the risk of malignancy.
41例淋巴瘤样丘疹病患者随访了1至22年（平均11.4年，中位数10年）。6例患者发展为恶性淋巴瘤，3例为皮肤T细胞淋巴瘤，2例为Ki-1大细胞淋巴瘤，1例为霍奇金病。临床恶性表现加上皮肤病变中发现非整倍体似乎提示有恶变潜能。低剂量甲氨蝶呤治疗是淋巴瘤样丘疹病的有效治疗方法，可能会降低恶变风险。
