He Shi-kun, Jiang Yan
Department of Ophthalmology, Keck School of Medicine at University of Southern California, Los Angeles, CA 90033, USA.
Zhonghua Yan Ke Za Zhi. 2006 Mar;42(3):278-82.
Aging is a common feature of biological changes in the eye, especially in the retina. It is recognized that the pathogenesis of age-related macular degeneration (AMD) involves changes of RPE-Bruch membrane and choroid capillaries complex, which includes function and structure abnormal in the complex accompanied with aging processes. Aging may be an important event to contribute to the pathogenesis of AMD, but aging dose not directly led to the occurrence of AMD, multifactor is involved in the initiation of the pathogenesis of AMD. Therefore, this review is summarizing the latest concepts of the rale of aging in the occurrence of AMD.
衰老眼部生物变化的一个常见特征，尤其是在视网膜中。人们认识到，年龄相关性黄斑变性（AMD）的发病机制涉及视网膜色素上皮（RPE）- Bruch膜和脉络膜毛细血管复合体的变化，这包括该复合体在衰老过程中功能和结构的异常。衰老可能是促成AMD发病机制的一个重要因素，但衰老并不会直接导致AMD的发生，AMD发病机制的启动涉及多种因素。因此，本综述总结了衰老在AMD发生中作用的最新概念。
