Spraul C W, Lang G E, Grossniklaus H E
Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2724-35.
To quantify morphologic changes in the choroid, including choriocapillaris and larger choroidal vessels, Bruch's membrane, and retinal pigment epithelium in eyes with age-related macular degeneration (AMD) and late ARM (age-related maculopathy).
The authors analyzed 40 eye bank eyes with late ARM (21 with the neovascular AMD and 19 with nonneovascular AMD) and compared them with 40 age-matched eyes without signs of late ARM (AMD). The eyes were processed for light microscopy, and seven variables were measured in the macular and peripheral regions with a digital filar micrometer.
There were no statistically significant differences observed between eyes with neovascular versus nonneovalcular AMD. The single most important difference between eyes with and without AMD was the amount of basal laminar deposit (P < 0.001). Eyes with AMD displayed fewer large choroidal vessels in the submacular choroid than eyes without AMD (3.5 +/- 1.5 mm-1 and 5.7 +/- 1.6 mm-1; P < 0.001). The submacular choriocapillaris density was higher in eyes with AMD (0.62 +/- 0.06) than in eyes without AMD (0.51 +/- 0.08; P < 0.001). The diameter of the large choroidal vessels in the peripheral choroid was increased in eyes with AMD (30 +/- 8 microns) compared to eyes without AMD (21.4 +/- 6.2 microns; P < 0.001). The peripheral choriocapillaris density displayed the same pattern as in the macular region in eyes with and without AMD.
The amount of basal laminar deposit strongly correlates with the histologic presence of AMD. Eyes with AMD show differences of the density and diameter of choroidal blood vessels compared to eyes without AMD.
量化年龄相关性黄斑变性（AMD）和晚期年龄相关性黄斑病变（ARM）患者眼中脉络膜的形态学变化，包括脉络膜毛细血管、较大的脉络膜血管、布鲁赫膜和视网膜色素上皮。
作者分析了40只晚期ARM眼库眼（21只患有新生血管性AMD，19只患有非新生血管性AMD），并将其与40只年龄匹配且无晚期ARM（AMD）体征的眼进行比较。对这些眼睛进行光镜处理，并用数字细丝测微计在黄斑区和周边区域测量七个变量。
新生血管性AMD眼与非新生血管性AMD眼之间未观察到统计学上的显著差异。有AMD和无AMD的眼睛之间唯一最重要的差异是基底膜沉积物的量（P < 0.001）。与无AMD的眼睛相比，患有AMD的眼睛黄斑下脉络膜中的大脉络膜血管较少（3.5 ± 1.5 mm-1和5.7 ± 1.6 mm-1；P < 0.001）。患有AMD的眼睛黄斑下脉络膜毛细血管密度高于无AMD的眼睛（0.62 ± 0.06）（0.51 ± 0.08；P < 0.001）。与无AMD的眼睛相比，患有AMD的眼睛周边脉络膜中大脉络膜血管的直径增加（30 ± 8微米）（21.4 ± 6.2微米；P < 0.001）。在有AMD和无AMD的眼睛中，周边脉络膜毛细血管密度与黄斑区呈现相同的模式。
基底膜沉积物的量与AMD的组织学表现密切相关。与无AMD的眼睛相比，患有AMD的眼睛脉络膜血管的密度和直径存在差异。
