Pornsuriyasak Papapida, Demchenko Alexei V
Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Blvd., St. Louis, MO 63121, USA.
Carbohydr Res. 2006 Jul 24;341(10):1458-66. doi: 10.1016/j.carres.2006.03.041. Epub 2006 Apr 27.
The synthesis of the tumor-associated carbohydrate antigens SSEA-3 and Gb3 in a semi-convergent fashion using building blocks bearing a S-thiazolinyl (STaz) moiety is reported. Complete stereoselective control of a difficult alpha-(1-->4)-galactosylation and high overall yields were achieved.
报道了使用带有S-噻唑啉基（STaz）部分的构建块以半汇聚方式合成肿瘤相关碳水化合物抗原SSEA-3和Gb3。实现了对困难的α-(1→4)-半乳糖基化的完全立体选择性控制和高总收率。
