Simonetti Oriana, Goteri Gaia, Lucarini Guendalina, Filosa Alessandra, Pieramici Tiziana, Rubini Corrado, Biagini Graziella, Offidani Annamaria
Clinica Dermatologica, Università Politecnica delle Marche, Ospedali Riuniti, Via Conca 71, 60020 Torrette (Ancona), Italy.
Eur J Cancer. 2006 May;42(8):1181-7. doi: 10.1016/j.ejca.2006.01.043. Epub 2006 Apr 27.
Aim of this study was to investigate using immunohistochemistry techniques the interrelation between T immunoreactive cells and the expression of CCR10 and its ligand CCL27 in 59 cutaneous melanocytic lesions. In malignant melanomas, T lymphocyte density was significantly decreased from thin melanomas to intermediate and thick ones (P<0.0005). CCR10 expression was found both in benign and malignant lesions and it was directly correlated with the Breslow depth (P=0.0298) and inversely with T lymphocyte density (P=0.0231). Moreover, cases with positive sentinel lymph node tended to have a higher CCR10 expression compared to cases with negative sentinel lymph node (P=0.0281). When CCR10 and CCL27 expression were evaluated together, CCR10-/CCL27-melanomas tended to have a higher mean density of CD3+ and CD8+ lymphocytes. Our results suggest that in human melanomas CCR10 and CCL27 may act to increase the ability of neoplastic cells to grow, invade tissue, disseminate to lymph nodes and to escape the host immune response.
本研究的目的是运用免疫组织化学技术，调查59例皮肤黑素细胞性病变中T免疫反应性细胞与CCR10及其配体CCL27表达之间的相互关系。在恶性黑色素瘤中，从薄型黑色素瘤到中等厚度和厚型黑色素瘤，T淋巴细胞密度显著降低（P<0.0005）。在良性和恶性病变中均发现CCR10表达，其与Breslow深度呈正相关（P=0.0298），与T淋巴细胞密度呈负相关（P=0.0231）。此外，前哨淋巴结阳性的病例与前哨淋巴结阴性的病例相比，CCR10表达往往更高（P=0.0281）。当同时评估CCR10和CCL27表达时，CCR10-/CCL27-黑色素瘤往往具有更高的CD3+和CD8+淋巴细胞平均密度。我们的结果表明，在人类黑色素瘤中，CCR10和CCL27可能起到增强肿瘤细胞生长、侵袭组织、扩散至淋巴结以及逃避宿主免疫反应的能力的作用。
