从木蓝中分离出的呋喃黄酮类化合物的抗血脂异常活性。
Antidyslipidemic activity of furano-flavonoids isolated from Indigofera tinctoria.
作者信息
Narender Tadigoppula, Khaliq Tanvir, Puri Anju, Chander Ramesh
机构信息
Division of Medicinal and Process Chemistry, Lucknow, India.
出版信息
Bioorg Med Chem Lett. 2006 Jul 1;16(13):3411-4. doi: 10.1016/j.bmcl.2006.04.001. Epub 2006 Apr 27.
Flavonoids appear to play a major role in reducing the risk of cardiovascular diseases by decreasing the blood lipid levels. In continuation of our drug discovery program on antidyslipidemic agents we have isolated three furano-flavones 1-3 and a rare flavonol glycoside 4 from the aerial parts of Indigofera tinctoria. Our results disclose that the treatment with diastereomeric flavonoid mixture 1 and 2 (80:20) significantly decreased the plasma triglycerides (TG) by 60%, total cholesterol (TC) 19%, glycerol (Gly) 13%, and free fatty acid (FFA) 25% accompanied with increase in high density lipoproteins-cholesterol (HDL-C) by 8% and HDL-C/TC ratio 36% in high fat diet (HFD) fed dyslipidemic hamsters at the dose of 50 mg/kg body weight. The flavonoid 3 has exhibited moderate antidyslipidemic activity.
类黄酮似乎在通过降低血脂水平来降低心血管疾病风险方面发挥着重要作用。在我们关于抗血脂异常药物的药物发现计划的延续中，我们从木蓝的地上部分分离出了三种呋喃黄酮1 - 3和一种罕见的黄酮醇苷4。我们的结果表明，用非对映体黄酮混合物1和2（80:20）以50 mg/kg体重的剂量处理高脂饮食（HFD）喂养的血脂异常仓鼠后，血浆甘油三酯（TG）显著降低60%，总胆固醇（TC）降低19%，甘油（Gly）降低13%，游离脂肪酸（FFA）降低25%，同时高密度脂蛋白胆固醇（HDL-C）增加8%，HDL-C/TC比值增加36%。黄酮3表现出中等的抗血脂异常活性。
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