Bahramikia Seifollah, Yazdanparast Razieh
Institute of Biochemistry and Biophysics, PO Box 13145-1384, University of Tehran, Tehran, Iran.
J Ethnopharmacol. 2008 Jan 4;115(1):116-21. doi: 10.1016/j.jep.2007.09.015. Epub 2007 Sep 25.
Nasturtium officinale R. Br. (Brassicaceae) is used as a home remedy in Iran as a cardioprotective agent without any scientific background. In this investigation an attempt was made to study the effect of Nasturtium officinale hydroalcoholic extract (NOE) on serum lipid profile which is closely associated with many cardiovascular diseases.
Accordingly, serum total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were among the parameters investigated. We also evaluated the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as a measure of hepatic cell damages.
Intragastric administration of NOE (500 mg/kg body weight per day) to groups of hypercholesterolaemic rats for 10 days lowered their serum TC, TG and LDL-C by 34.2, 30.1, and 52.9%, respectively, while raised the serum HDL-C level by 27.0% after 10 days of treatments. Treatment with NOE reduced serum ALT and AST levels compared to high-fat diet groups.
Based on these data, it is concluded that the NOE has definite cardioprotective potential and these results constitute a valid scientific basis for consuming Nasturtium officinale for medicinal application.
水田芥（十字花科）在伊朗被用作家庭疗法中的心脏保护剂，但没有任何科学依据。在本研究中，试图研究水田芥水醇提取物（NOE）对与许多心血管疾病密切相关的血清脂质谱的影响。
相应地，血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）是所研究的参数。我们还评估了血清天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）水平的活性，作为肝细胞损伤的指标。
给高胆固醇血症大鼠组每天灌胃NOE（500毫克/千克体重），持续10天，其血清TC、TG和LDL-C分别降低了34.2%、30.1%和52.9%，而在治疗10天后血清HDL-C水平升高了27.0%。与高脂饮食组相比，用NOE治疗可降低血清ALT和AST水平。
基于这些数据，得出结论，NOE具有明确的心脏保护潜力，这些结果为水田芥用于药用提供了有效的科学依据。
