Perveen Shagufta, Khan Sher Bahadar, Malik Abdul, Tareen Rasool Bakhsh, Nawaz Sarfraz Ahmad, Choudhary Muhammad Iqbal
International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan.
Nat Prod Res. 2006 Apr;20(4):347-53. doi: 10.1080/14786410500463205.
Perovskoate, an isorinic acid derivative (1) and perovskoside, the catechol derivative (2) have been isolated from the ethyl acetate soluble fraction of the whole plant of Perovskia atriplicifolia and assigned the structure 3(7-hydroxyphenyl)-2-hydroxy propanoic acid; (R)-form, 2-O-(6',7'-dihydroxy-E-cinnamoyl) (1) and 2-methoxy-4-(undecyl-4'-O-beta-D-glucopyranosyl) phenol (2). In addition, caffeic acid (3) and ferulic acid (4) have been reported for the first time from this species. The structures of these compounds were assigned on the basis of 1D and 2D NMR techniques. The compound 1 showed significant inhibitory activity against lipoxygenase and weak to moderate activity against cholinesterases.
从灰毛蕊花全株的乙酸乙酯可溶部分中分离出异藜芦酸衍生物（1）紫苏酮和儿茶酚衍生物（2），并确定其结构为3-(7-羟基苯基)-2-羟基丙酸；（R）-形式、2-O-(6',7'-二羟基-E-肉桂酰基)（1）和2-甲氧基-4-(十一烷基-4'-O-β-D-吡喃葡萄糖基)苯酚（2）。此外，首次从该物种中报道了咖啡酸（3）和阿魏酸（4）。这些化合物的结构是根据一维和二维核磁共振技术确定的。化合物1对脂氧合酶表现出显著的抑制活性，对胆碱酯酶表现出弱至中等活性。
