提取物作为一种有望用于皮肤局部应用的保护性原料的评估。

Evaluation of Extract as a Promising Protective Raw Material Applied Topically to the Skin.

作者信息

Michalak Monika, Zagórska-Dziok Martyna, Żarnowiec Paulina, Ostróżka-Cieślik Aneta, Bocho-Janiszewska Anita, Stryjecka Małgorzata, Dobros Natalia, Kostrzewa Dorota, Paradowska Katarzyna

机构信息

Department of Pharmaceutical Sciences, Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc 19, 35-317 Kielce, Poland.

Department of Technology of Cosmetic and Pharmaceutical Products, Medical College, University of Information Technology and Management in Rzeszów, Sucharskiego 2, 35-225 Rzeszów, Poland.

出版信息

Molecules. 2025 Aug 27;30(17):3505. doi: 10.3390/molecules30173505.

DOI:10.3390/molecules30173505

PMID:40942033

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12430148/

Abstract

is a popular garden plant known for its medicinal properties. The aim of this study was to evaluate the chemical composition and skin protective properties of extracts, which have not previously been studied in this regard. Comparison of the water-ethanol extract obtained by ultrasound-assisted extraction (UAE) with a CO extract showed that the former had higher content of polyphenolic compounds. Chromatographic analyses of UAE identified such phenolic compounds as rosmarinic acid, hesperidin, and caffeic acid. The biological properties of UAE were also tested in vitro on 15 microbial strains as well as on two lines of skin cells. In addition, a hydrogel and lotion based on the extract were tested for rheological and textural properties. This study showed that extract can be a valuable natural cosmetic material owing to its antimicrobial, antioxidant, photoprotective, and anti-aging effects. The future use of extracts in the cosmetic industry is promising due to its particular chemical profile and biological properties.

摘要

是一种以其药用特性而闻名的常见园林植物。本研究的目的是评估提取物的化学成分和皮肤保护特性，此前尚未在这方面进行过研究。将超声辅助提取（UAE）获得的水-乙醇提取物与CO提取物进行比较，结果表明前者的多酚类化合物含量更高。UAE的色谱分析鉴定出迷迭香酸、橙皮苷和咖啡酸等酚类化合物。还在15种微生物菌株以及两株皮肤细胞系上对UAE的生物学特性进行了体外测试。此外，还对基于该提取物的水凝胶和乳液的流变学和质地特性进行了测试。这项研究表明，该提取物由于其抗菌、抗氧化、光保护和抗衰老作用，可成为一种有价值的天然化妆品原料。由于其独特的化学特征和生物学特性，该提取物未来在化妆品行业的应用前景广阔。