Houben M P W A, Aben K K H, Teepen J L J M, Schouten-Van Meeteren A Y N, Tijssen C C, Van Duijn C M, Coebergh J W W
Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands.
Acta Oncol. 2006;45(3):272-9. doi: 10.1080/02841860500543190.
Time trends in the incidence of glioma may reflect changes in the prevalence of environmental risk factors for glioma. We therefore investigated trends in the incidence of childhood and adult glioma in The Netherlands from 1989 to 2003. We used population-based incidence data from the Netherlands Cancer Registry. We calculated European standardised incidence rates for glioma, and stratified for age, gender and glioma subgroups. Changes in the incidence were estimated by calculating the Estimated Annual Percentage Change. Similar to other countries, the overall incidence of glioma was fairly stable in The Netherlands during the period 1989 to 2003, for both children and adults. In adult astrocytic glioma, a significantly increasing incidence of high-grade astrocytoma was balanced by simultaneous decreases of low-grade astrocytoma, astrocytoma with unknown malignancy grade and glioma of uncertain histology. Most of these time trends can be explained by improving detection and diagnostic precision. Stable incidence rates of adult and childhood glioma suggest that no major changes in environmental risk factors have occurred, which influenced the incidence of glioma in the studied period.
胶质瘤发病率的时间趋势可能反映了胶质瘤环境危险因素流行率的变化。因此，我们调查了1989年至2003年荷兰儿童和成人胶质瘤的发病率趋势。我们使用了荷兰癌症登记处基于人群的发病率数据。我们计算了胶质瘤的欧洲标准化发病率，并按年龄、性别和胶质瘤亚组进行了分层。通过计算估计年变化百分比来估计发病率的变化。与其他国家类似，1989年至2003年期间，荷兰儿童和成人的胶质瘤总体发病率相当稳定。在成人星形细胞瘤中，高级别星形细胞瘤发病率的显著增加被低级别星形细胞瘤、恶性程度未知的星形细胞瘤和组织学不确定的胶质瘤的同时减少所平衡。这些时间趋势大多可以通过检测和诊断精度的提高来解释。成人和儿童胶质瘤发病率稳定表明，在所研究的时期内，影响胶质瘤发病率的环境危险因素没有发生重大变化。
