Mao Y, Desmeules M, Semenciw R M, Hill G, Gaudette L, Wigle D T
Surveillance and Risk Assessment Division, Department of National Health and Welfare, Ottawa, Ont.
CMAJ. 1991 Dec 15;145(12):1583-91.
To analyse brain cancer patterns in Canada, particularly according to age and sex distributions, temporal patterns and regional variations. Changes in diagnostic techniques, survival rates and trends by tumour type were also examined.
Descriptive epidemiologic study based on Canada-wide population data for 1959-88.
Rates of death, incidence and admission to hospital because of brain cancer, as well as survival time and methods of diagnosis.
Incidence and death rates and time trends were examined for Canada as a whole, by province and by census division.
The rates of death from brain cancer increased rapidly among Canadians aged 55 years or more from 1959 to 1988. In particular, age-adjusted death rates increased by 117%, 797% and 118% among men 65 to 74 years, 75 to 84 and 85 or more respectively. The corresponding increases among women were 138%, 535% and 400%. The incidence rates also increased substantially. The trends in incidence rates by tumour type indicated that the increase was more pronounced for glioblastomas. The incidence rates of cases detected histologically, radiologically and clinically all increased.
Because glioblastomas are generally easier to diagnose than astrocytomas and because the incidence rates of glioblastomas were found to increase substantially, the increased brain cancer rates among elderly people may not be entirely attributable to improved diagnostic techniques. However, analytic investigations of the impact of changes in diagnostic procedures on brain cancer trends are needed to clarify this issue.
分析加拿大脑癌的发病模式，特别是根据年龄和性别分布、时间模式及地区差异进行分析。还研究了诊断技术、生存率的变化以及不同肿瘤类型的趋势。
基于1959 - 1988年加拿大全国人口数据的描述性流行病学研究。
脑癌的死亡率、发病率、因脑癌住院率，以及生存时间和诊断方法。
对加拿大整体、各省及人口普查区的发病率、死亡率和时间趋势进行研究。
1959年至1988年期间，55岁及以上加拿大人的脑癌死亡率迅速上升。特别是，65至74岁男性的年龄调整死亡率分别上升了117%、75至84岁男性上升了797%、85岁及以上男性上升了118%。女性相应的上升幅度分别为138%、535%和400%。发病率也大幅上升。按肿瘤类型划分的发病率趋势表明，胶质母细胞瘤的上升更为明显。通过组织学、放射学和临床检测出的病例发病率均有所上升。
由于胶质母细胞瘤通常比星形细胞瘤更容易诊断，且发现胶质母细胞瘤的发病率大幅上升，老年人脑癌发病率的上升可能并非完全归因于诊断技术的改进。然而，需要对诊断程序变化对脑癌趋势的影响进行分析研究，以阐明这一问题。
