Zaccariotto T R, Rosim E T, Melo D, Garcia P M D, Munhoz R R, Aoki F H, de Fatima Sonati M
Clinical Pathology Department, School of Medical Sciences, State University of Campinas-UNICAMP, Campinas, São Paulo State, Brazil.
J Clin Pathol. 2006 May;59(5):550-3. doi: 10.1136/jcp.2005.027375.
Haptoglobin (Hp) is a plasma protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinctive efficiencies in their activities and have been related to susceptibility and outcome in different diseases, including HIV infection.
To compare Hp genotype distribution between HIV-1 seropositive patients and healthy controls.
387 Brazilian HIV-1 seropositive patients, subclassified as A, B, and C according to the Centers for Disease Control, were compared with 142 healthy controls. The influence of the polymorphism on iron status (serum iron, ferritin, transferrin, transferrin saturation), acute phase proteins (Hp, C reactive protein, fibrinogen, albumin), the HIV-1 viral load, and CD4+ T lymphocyte counts was examined.
Apart from finding lower Hp concentrations among individuals with genotype Hp2-2, no other significant difference was observed.
No association was found between Hp genotype and either HIV status or indices of HIV progression.
触珠蛋白（Hp）是一种具有抗氧化和免疫调节特性的血浆蛋白。三种主要的基因型/表型（Hp1-1、Hp2-1、Hp2-2）在其活性方面表现出独特的效率，并且与包括HIV感染在内的不同疾病的易感性和预后相关。
比较HIV-1血清阳性患者和健康对照之间的Hp基因型分布。
根据疾病控制中心的分类，将387名巴西HIV-1血清阳性患者分为A、B和C亚组，并与142名健康对照进行比较。研究了该多态性对铁状态（血清铁、铁蛋白、转铁蛋白、转铁蛋白饱和度）、急性期蛋白（Hp、C反应蛋白、纤维蛋白原、白蛋白）、HIV-1病毒载量和CD4+T淋巴细胞计数的影响。
除了发现Hp2-2基因型个体的Hp浓度较低外，未观察到其他显著差异。
未发现Hp基因型与HIV状态或HIV进展指标之间存在关联。
