Ogunro P S, Idogun E S, Ogungbamigbe T O, Ajala M O, Olowu O A
Department of Chemical Pathology, College of Medicine, Lagos State University, Lagos.
Niger Postgrad Med J. 2008 Dec;15(4):219-24.
To evaluate the effect of HIV-1 infection and its progression on lipid profiles, acute-phase proteins and to determine which of the parameters may serve as an early indicator of the progression of HIV infection.
A cross-sectional study was conducted on sixty-two HIV-1 infected subjects attending HIV clinic, the patients consisted of 29 males and 33 females aged between 20-60 years (mean age 31+/- 7 years) who were screened for HIV-1 by ELISA test. Absolute CD4+ T lymphocyte was counted and HIV infected individuals were classified according to the Centre for Disease Control and Prevention (CDC) Criteria; CD4+ counts e"500/mm3 (asymptomatic), CD4+ counts 200-499/mm3 (symptomatic) and CD4+ counts d"199/mm3 (symptomatic) with full blown AIDS. Serum concentrations of total protein, albumin, gamma globulin, acute-phase protein, and lipid profile were determined.
There was significantly increased gamma globulin fraction of the serum protein in HIV patients with CD4+ counts of e"500/mm3, 200-499/mm3 and d"199/mm3 when compared with the controls. Serum triglyceride was significantly increased in HIV patients with CD4+ counts of d"199/mm3 only, whereas a significantly decreased serum HDL-cholesterol in HIV patients with CD4+ counts of 200-499/mm3 and d"199/mm3 was found when compared with the controls. Haptoglobin, C-reactive protein and a1-acid glycoprotein were significantly increased in HIV patients with CD4+ counts of 200-499/mm3 and d"199/mm3 when compared with the controls. However, albumin was significantly reduced in HIV patients with CD4+ counts of d"199/mm3 when compared with the controls. There was direct correlation between HDL-cholesterol and the CD4+ counts, on the other hand, an inverse correlation between C-reactive protein, haptoglobin and a1-acid glycoprotein against CD4+ counts was found.
A decreased HDL-cholesterol had direct correlation with the CD4+ counts in all the stages of HIV infection; however, increased haptoglobin and C-reactive protein had inverse correlation with the CD4+ counts in all the stages of HIV infection. Therefore HDL-cholesterol, C-reactive protein and haptoglobin may serve as indicators of disease progression in HIV infection.
评估HIV-1感染及其进展对血脂谱、急性期蛋白的影响，并确定哪些参数可作为HIV感染进展的早期指标。
对62名在HIV诊所就诊的HIV-1感染受试者进行了一项横断面研究。患者包括29名男性和33名女性，年龄在20至60岁之间（平均年龄31±7岁），通过ELISA检测筛查HIV-1。计数绝对CD4+T淋巴细胞，并根据疾病控制与预防中心（CDC）标准对HIV感染者进行分类；CD4+计数≥500/mm3（无症状）、CD4+计数200 - 499/mm3（有症状）和CD4+计数≤199/mm3（有症状且患有全面性艾滋病）。测定血清总蛋白、白蛋白、γ球蛋白、急性期蛋白和血脂谱。
与对照组相比，CD4+计数≥500/mm3、200 - 499/mm3和≤199/mm3的HIV患者血清蛋白中的γ球蛋白部分显著增加。仅CD4+计数≤199/mm3的HIV患者血清甘油三酯显著增加，而与对照组相比，CD4+计数200 - 499/mm3和≤199/mm3的HIV患者血清高密度脂蛋白胆固醇显著降低。与对照组相比，CD4+计数200 - 499/mm3和≤199/mm3的HIV患者触珠蛋白、C反应蛋白和α1-酸性糖蛋白显著增加。然而，与对照组相比，CD4+计数≤199/mm3的HIV患者白蛋白显著降低。高密度脂蛋白胆固醇与CD4+计数呈直接相关性，另一方面，发现C反应蛋白、触珠蛋白和α1-酸性糖蛋白与CD4+计数呈负相关。
在HIV感染的所有阶段，高密度脂蛋白胆固醇降低与CD4+计数呈直接相关；然而，在HIV感染的所有阶段，触珠蛋白和C反应蛋白增加与CD4+计数呈负相关。因此，高密度脂蛋白胆固醇、C反应蛋白和触珠蛋白可作为HIV感染疾病进展的指标。
