血管性痴呆中载脂蛋白E ε4等位基因频率
Apolipoprotein E epsilon4 allele frequency in vascular dementia.
作者信息
Davidson Yvonne, Gibbons Linda, Purandare Nitin, Byrne Jane, Hardicre Jayne, Wren Joanne, Payton Antony, Pendleton Neil, Horan Michael, Burns Alistair, Mann David M A
机构信息
Clinical Neuroscience Research Group, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK.
出版信息
Dement Geriatr Cogn Disord. 2006;22(1):15-9. doi: 10.1159/000092960. Epub 2006 Apr 25.
AIM
The aim of the study was to investigate whether possession of the epsilon4 allelic form of the apolipoprotein E (APOE) gene increases the risk of developing vascular dementia (VaD).
METHODS
APOE allele and genotype frequencies were determined by PCR in 89 patients with possible and probable VaD and compared with those in 97 patients with possible and probable Alzheimer's disease (AD) of similar age of disease onset and ethnic background, and with 766 control subjects drawn from the same geographical region.
RESULTS
The APOE epsilon4 allele frequency in all 97 patients with possible and probable AD was significantly higher (p < 0.001) than that in control subjects. However, the APOE epsilon4 allele frequency in all 89 patients with possible and probable VaD was also significantly higher (p < 0.001) than that in control subjects, but not significantly different from that in AD. The APOE epsilon4 allele frequency was similarly, and still significantly (p < 0.001), increased when only those patients with probable AD or probable VaD were considered.
CONCLUSION
Possession of APOE epsilon4 allele increases the risk of VaD.
目的
本研究旨在调查载脂蛋白E（APOE）基因的ε4等位基因形式是否会增加患血管性痴呆（VaD）的风险。
方法
采用聚合酶链反应（PCR）测定89例可能患有或确诊为VaD的患者的APOE等位基因和基因型频率，并与97例年龄发病和种族背景相似的可能患有或确诊为阿尔茨海默病（AD）的患者以及766名来自同一地理区域的对照受试者进行比较。
结果
所有97例可能患有或确诊为AD的患者中APOE ε4等位基因频率显著高于对照受试者（p<0.001）。然而，所有89例可能患有或确诊为VaD的患者中APOE ε4等位基因频率也显著高于对照受试者（p<0.001），但与AD患者无显著差异。仅考虑确诊为AD或确诊为VaD的患者时，APOE ε4等位基因频率同样显著升高（p<0.001）。
结论
携带APOE ε4等位基因会增加患VaD的风险。
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