载脂蛋白 E 基因型与痴呆症谱系的长寿。

Apolipoprotein E genotypes and longevity across dementia disorders.

机构信息

Department of Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.

出版信息

Alzheimers Dement. 2018 Jul;14(7):895-901. doi: 10.1016/j.jalz.2018.02.003. Epub 2018 Mar 13.

DOI:10.1016/j.jalz.2018.02.003

PMID:29548722

Abstract

INTRODUCTION

The ε4 allele of the apolipoprotein E (APOE) gene is a prominent risk factor for Alzheimer's disease (AD), but its implication in other dementias is less well studied.

METHODS

We used a data set on 2858 subjects (1098 AD, 260 vascular dementia [VaD], 145 mixed AD and VaD, 90 other dementia diagnoses, and 1265 controls) to examine the association of APOE polymorphisms with clinical dementia diagnoses, biomarker profiles, and longevity.

RESULTS

The ε4 allele was associated with reduced longevity as ε4 versus ε3 homozygotes lived on average 2.6 years shorter (P = .006). In AD, ε4 carriers lived 1.0 years shorter than noncarriers (P = .028). The ε4 allele was more prevalent in AD, mixed AD and VaD, and VaD patients compared to controls, but not in other dementia disorders.

DISCUSSION

The APOE ε4 allele is influential in AD but might also be of importance in VaD and in mixed AD and VaD, diseases in which concomitant AD pathology is common.

摘要

简介

载脂蛋白 E（APOE）基因的 ε4 等位基因是阿尔茨海默病（AD）的一个重要风险因素，但它在其他痴呆症中的作用研究较少。

方法

我们使用了一个包含 2858 名受试者的数据组（1098 名 AD、260 名血管性痴呆[VaD]、145 名 AD 和 VaD 混合、90 名其他痴呆诊断和 1265 名对照），以检查 APOE 多态性与临床痴呆诊断、生物标志物特征和长寿的关系。

结果

ε4 等位基因与寿命缩短相关，ε4 纯合子比 ε3 纯合子的平均寿命缩短 2.6 年（P = 0.006）。在 AD 中，ε4 携带者的寿命比非携带者短 1.0 年（P = 0.028）。与对照组相比，ε4 等位基因在 AD、AD 和 VaD 混合、VaD 患者中更为常见，但在其他痴呆症中并非如此。