Ayo J O, Minka N S, Mamman M
Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria.
J Vet Sci. 2006 Jun;7(2):127-31. doi: 10.4142/jvs.2006.7.2.127.
In this study, we investigated the effect of ascorbic acid (AA) administration on goat excitability due to transportation. Ten goats administered AA (p.o.) at 100 mg/kg of body weight before transportation served as the experimental group, and seven goats administered only 10 ml/kg of sterile water (p.o.) served as controls. Excitability scores were recorded for each goat; when weighed, before, immediately after, and 3 h after 8 h of transportation. A score of one to four was allocated to each goat; higher scores represent greater excitability. Immediately after transportation, excitability scores decreased significantly, especially those of control goats (p < 0.001). At 3 h posttransportation, the excitability scores of animals in the experimental group were not significantly (p > 0.05) different from their pre-transportation normal values, whereas those of control goats were significantly lower (p < 0.01). The correlation i.e. the relationship between excitability score values and percent excitability (percentage of goat with particular excitability score) for different excitability score group 3 h post-transportation was positive and highly significant (p < 0.001), in both experimental and control goats. Our results indicate that road transportation induces considerable stress (depression) in goats as evidenced by a lower excitability score posttransportation. Moreover, the administration of AA pretransportation facilitated the transition from a state of depression to excitation. In conclusion, AA administration to animals prior to transportation may ameliorate the depression often encountered after road transportation.
在本研究中,我们调查了抗坏血酸(AA)给药对运输引起的山羊兴奋性的影响。十只山羊在运输前按每千克体重100毫克的剂量口服AA作为实验组,七只山羊仅口服每千克体重10毫升的无菌水作为对照组。记录每只山羊的兴奋性评分;在称重时,分别在运输前、运输8小时后立即以及运输8小时后3小时进行。每只山羊的评分从1到4分;分数越高表示兴奋性越高。运输后立即发现,兴奋性评分显著下降,尤其是对照组山羊(p<0.001)。运输后3小时,实验组动物的兴奋性评分与运输前的正常水平无显著差异(p>0.05),而对照组山羊的兴奋性评分则显著较低(p<0.01)。运输后3小时,实验组和对照组山羊不同兴奋性评分组的兴奋性评分值与兴奋性百分比(具有特定兴奋性评分的山羊百分比)之间的相关性呈正相关且高度显著(p<0.001)。我们的结果表明,道路运输会给山羊带来相当大的应激(抑郁),运输后兴奋性评分降低就证明了这一点。此外,运输前给予AA有助于从抑郁状态转变为兴奋状态。总之,在运输前给动物施用AA可能会改善道路运输后经常出现的抑郁情况。