Schäfer Torsten, Merkl Jessica, Klemm Eckart, Wichmann Heinz-Erich, Ring Johannes
Institute of Social Medicine, Medical University of Luebeck, Luebeck, Germany.
J Invest Dermatol. 2006 Jul;126(7):1490-6. doi: 10.1038/sj.jid.5700269. Epub 2006 Apr 27.
Nevi can approximate the melanoma risk and demographic changes will increase the meaning of signs of skin aging (SSA). However, little is known about the epidemiology of nevi and SSA in the general adult population. We aimed to estimate the prevalence and age distribution of common and atypical nevi and SSA as well as gender differences in a large population-based sample. Within the Cooperative Health Research in the Augsburg Region (KORA) in Germany, a population-based survey was performed. Data were gathered by interview and the number of pigmented lesions and presence of SSA were obtained by dermatological examination. A total of 2,823 adults (mean age 49 years, 50% women) participated (response 67%). Most subjects (60.3%) exhibited 11 to 50 common nevi and 5.2% had at least one atypical nevus. 51.9% were diagnosed with elastosis (Cutis rhomboidalis nuchae, 18.3%; Morbus Favre Racouchot 1.4%). Ephelides were seen in 16%, lentigines solaris in 62.4%, and lentigines seniles in 33.2%. All signs of skin aging increased significantly with age and so did lentigines solaris, seniles, and actinic keratoses. In contrast, common and atypical nevi and ephelides decreased significantly with age. Signs of skin aging are frequent and increase, in contrast to common and atypical nevi, with age.
痣可近似反映黑色素瘤风险，而人口结构变化将增加皮肤老化体征（SSA）的意义。然而，对于普通成年人群中痣和SSA的流行病学情况知之甚少。我们旨在估计一个基于大规模人群样本中普通痣、非典型痣和SSA的患病率、年龄分布以及性别差异。在德国奥格斯堡地区合作健康研究（KORA）中，开展了一项基于人群的调查。通过访谈收集数据，并通过皮肤科检查获取色素沉着病变的数量和SSA的存在情况。共有2823名成年人（平均年龄49岁，50%为女性）参与（应答率67%）。大多数受试者（60.3%）有11至50颗普通痣，5.2%至少有一颗非典型痣。51.9%被诊断为皮肤弹性组织变性（项部菱形皮肤，18.3%；法夫尔-拉库肖病，1.4%）。雀斑见于16%的人，日光性雀斑样痣见于62.4%的人，老年性雀斑样痣见于33.2%的人。所有皮肤老化体征均随年龄显著增加，日光性雀斑样痣、老年性雀斑样痣和光化性角化病也是如此。相比之下，普通痣、非典型痣和雀斑随年龄显著减少。皮肤老化体征常见且与普通痣和非典型痣不同，会随年龄增加。
