Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.
Division of Physiology, Otto-Loewi Research Center for Vascular Biology, Immunology and Inflammation, Medical University of Graz, Graz, Austria.
PLoS One. 2021 Jul 20;16(7):e0254772. doi: 10.1371/journal.pone.0254772. eCollection 2021.
Melanocytic nevi have a complex evolution influenced by several endogenous and exogenous factors and are known risk factors for malignant melanoma. Interestingly, tobacco use seems to be inversely associated with melanoma risk. However, the association between tobacco use and nevi and lentigines has not yet been evaluated.
We investigated the prevalence of nevi, atypical nevi, and lentigines in relation to tobacco smoking in a cohort of 59 smokers and 60 age- and sex-matched nonsmokers, using a questionnaire and performing a total body skin examination by experts.
No significant differences were detected between smokers and nonsmokers in the numbers of nevi, atypical nevi, and lentigines in sun-exposed areas (p = 0.966, 0.326, and 0.241, respectively) and in non-sun-exposed areas (p = 0.095, 0.351, and 0.546, respectively).
Our results revealed no significant differences in the prevalence of nevi, atypical nevi, and lentigines between smokers and nonsmokers in sun-exposed and non-sun-exposed areas.
黑素细胞痣的演变较为复杂，受到多种内源性和外源性因素的影响，它是恶性黑色素瘤的已知危险因素。有趣的是，吸烟似乎与黑色素瘤风险呈负相关。然而，吸烟与痣和黑子之间的关系尚未得到评估。
我们通过问卷调查和专家进行全身皮肤检查，在 59 名吸烟者和 60 名年龄和性别匹配的非吸烟者中，调查了痣、不典型痣和黑子的患病率与吸烟之间的关系。
在暴露于阳光的区域（p = 0.966、0.326 和 0.241）和非暴露于阳光的区域（p = 0.095、0.351 和 0.546），吸烟者和不吸烟者之间的痣、不典型痣和黑子数量均无显著差异。
我们的研究结果表明，在暴露于阳光和非暴露于阳光的区域，吸烟者和不吸烟者之间的痣、不典型痣和黑子的患病率无显著差异。
