Noradina A T, Hamidon B B, Roslan H, Raymond A A
Department of Medicine, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff Bandar Tun Razak, Cheras, Kuala Lumpur.
Singapore Med J. 2006 May;47(5):392-9.
There are several studies that reported a higher frequency of sleep-disordered breathing (SDB) among ischaemic stroke patients with increasing evidence linking SDB and cardiovascular complications. Many showed prevalence between 43 percent and 72 percent, taking the apnoea-hypopnoea index (AHI) equal to or greater than ten. The main objective of this study was to determine the frequency of SDB in recent ischaemic stroke patients admitted to Hospital Universiti Kebangsaan Malaysia (HUKM) and the relationship between SDB and known risk factors of ischaemic stroke.
This was a cross-sectional, prospective study involving 28 consecutive acute ischaemic stroke patients admitted to HUKM over three months. Sleep studies were done within one to four weeks after stroke onset. Demographical data and associated risk factors were recorded and data were analysed.
There were 20 men and eight women, with mean age of 60.3 +/- 8.9 years. There were eight Malay, 16 Chinese and four Indian patients. The prevalence of SDB in ischaemic stroke depending on the AHI cut-off was: 92.8 percent for AHI greater than or equal to five, 78.5 percent for AHI greater than or equal to ten, 44.5 percent for AHI greater than or equal to 15, and 37.7 percent for AHI greater than or equal to 20. We discovered that diabetes mellitus and smoking history were important factors predicting significant SDB (AHI greater than or equal to 15) in recent ischaemic stroke cases.
There was a high prevalence of SDB in recent ischaemic stroke patients in HUKM, comparable to other studies. Diabetes mellitus and smoking history were strong predictors of the occurrence of SDB after an ischaemic stroke.
有多项研究报告称，缺血性中风患者中睡眠呼吸障碍（SDB）的发生率较高，且越来越多的证据表明SDB与心血管并发症有关。许多研究显示，以呼吸暂停低通气指数（AHI）等于或大于10计算，患病率在43%至72%之间。本研究的主要目的是确定马来西亚国立大学医院（HUKM）近期收治的缺血性中风患者中SDB的发生率，以及SDB与已知缺血性中风危险因素之间的关系。
这是一项横断面前瞻性研究，纳入了连续三个月内在HUKM收治的28例急性缺血性中风患者。在中风发作后的1至4周内进行睡眠研究。记录人口统计学数据和相关危险因素，并进行数据分析。
共有20名男性和8名女性，平均年龄为60.3±8.9岁。其中有8名马来族、16名华裔和4名印度裔患者。根据AHI临界值，缺血性中风患者中SDB的患病率分别为：AHI大于或等于5时为92.8%，AHI大于或等于10时为78.5%，AHI大于或等于15时为44.5%，AHI大于或等于20时为37.7%。我们发现，糖尿病和吸烟史是近期缺血性中风病例中显著SDB（AHI大于或等于15）的重要预测因素。
HUKM近期缺血性中风患者中SDB的患病率较高，与其他研究相当。糖尿病和吸烟史是缺血性中风后发生SDB的有力预测因素。
