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急性缺血性卒中后吞咽困难的危险因素及预后

Risk factors and outcome of dysphagia after an acute ischaemic stroke.

作者信息

Hamidon B B, Nabil I, Raymond A A

机构信息

Department of Medicine, Faculty of Medicine UKM, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur.

出版信息

Med J Malaysia. 2006 Dec;61(5):553-7.

Abstract

Dysphagia occurs frequently after a stroke. It is a major problem as patients are at risk of malnutrition and aspiration pneumonia. We aimed to identify the risk factors for and outcome of dysphagia over the first one month after an acute ischaemic stroke. Patients with acute first-ever ischaemic stroke admitted to the medical ward of Hospital Universiti Kebangsaan Malaysia (HUKM) between July 2004 and December 2004 were prospectively examined. Observation was done using pre-defined criteria. Demographic data, risk factors, and type of stroke were recorded on admission. The assessment of dysphagia was made using standardized clinical methods. All patients were followed up for three months. One hundred and thirty four patients were recruited in the study. Fifty-five patients (41%) had dysphagia at presentation. This number was reduced to 29 (21.6%) patients at one month. Logistic regression analysis revealed that age of more than 75 years [OR 5.20 (95% CI 1.89 - 14.30)], diabetes mellitus [OR 2.91 (95% CI 1.07 - 7.91)] and MCA infarct [OR 2.48 (95% CI 1.01-6.14)] independently predicts the occurrence of dysphagia after an acute stroke. Dysphagia at presentation was found to be an independent predictor of mortality at one-month [OR 5.28 (95% CI 1.51-18.45)] post ischaemic infarct. Dysphagia occurred commonly in ischaemic stroke. Advance age, diabetes mellitus and large infarcts were independently associated with the presence of dysphagia. Early stroke mortality can be independently predicted by the presence of dysphagia.

摘要

吞咽困难在中风后很常见。这是一个主要问题,因为患者有营养不良和吸入性肺炎的风险。我们旨在确定急性缺血性中风后第一个月内吞咽困难的风险因素和结局。对2004年7月至2004年12月期间入住马来西亚国民大学医院(HUKM)内科病房的首次急性缺血性中风患者进行前瞻性检查。使用预先定义的标准进行观察。入院时记录人口统计学数据、风险因素和中风类型。采用标准化临床方法评估吞咽困难。所有患者均随访三个月。该研究共招募了134名患者。55名患者(41%)在就诊时存在吞咽困难。这个数字在一个月时降至29名患者(21.6%)。逻辑回归分析显示,年龄超过75岁[比值比5.20(95%可信区间1.89 - 14.30)]、糖尿病[比值比2.91(95%可信区间1.07 - 7.91)]和大脑中动脉梗死[比值比2.48(95%可信区间1.01 - 6.14)]独立预测急性中风后吞咽困难的发生。就诊时的吞咽困难被发现是缺血性梗死后一个月死亡率的独立预测因素[比值比5.28(95%可信区间1.51 - 18.45)]。吞咽困难在缺血性中风中很常见。高龄、糖尿病和大面积梗死与吞咽困难的存在独立相关。吞咽困难的存在可独立预测早期中风死亡率。

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