Momose-Sato Y, Sato K
Department of Physiology, Tokyo Medical and Dental University, Graduate School and Faculty of Medicine, Bunkyo-ku, Japan.
J Membr Biol. 2005 Nov;208(2):183-91. doi: 10.1007/s00232-005-0829-5.
Using multiple-site optical recording with the voltage-sensitive dye, NK2761, we found that vagus nerve stimulation in the embryonic chick brainstem elicits postsynaptic responses in an undefined region on the contralateral side. The characteristics of the contralateral optical signals suggested that they correspond to the monosynaptic response that is related to the vagal afferent fibers. The location of the contralateral response was different from the vagal motor nucleus (the dorsal motor nucleus of the vagus nerve) and sensory nucleus (the nucleus of the tractus solitarius), and other brainstem nuclei that receive primary vagal projection. These results show that the vagus nerve innervates and makes functional synaptic connections in a previously unreported region of the brainstem, and suggest that sensory information processing mediated by the vagus nerve is more complex than expected.
我们使用电压敏感染料NK2761进行多部位光学记录，发现胚胎期鸡脑干中的迷走神经刺激在对侧一个未明确的区域引发突触后反应。对侧光学信号的特征表明，它们对应于与迷走传入纤维相关的单突触反应。对侧反应的位置不同于迷走运动核（迷走神经背运动核）、感觉核（孤束核）以及其他接受迷走神经初级投射的脑干核。这些结果表明，迷走神经在脑干一个先前未报道的区域进行支配并建立功能性突触连接，提示迷走神经介导的感觉信息处理比预期更为复杂。
