通过肾脏序贯闪烁显像术评估0至18岁可能正常的大样本队列受试者的（123）I-邻碘马尿酸单肾清除率。

Evaluation of (123)I-orthoiodohippurate single kidney clearance rate by renal sequential scintigraphy in a large cohort of likely normal subjects aged between 0 and 18 years.

作者信息

Imperiale Alessio, Olianti Catia, Comis Giannetto, La Cava Giuseppe

机构信息

Department of Clinical Pathophysiology, University of Florence, Florence, Italy.

出版信息

Eur J Nucl Med Mol Imaging. 2006 Dec;33(12):1483-90. doi: 10.1007/s00259-006-0074-x. Epub 2006 Apr 28.

DOI:10.1007/s00259-006-0074-x

PMID:16645840

Abstract

PURPOSE

Age-related values of (123)I-orthoiodohippurate (OIH) single kidney clearance rate (Cl) were estimated in a large cohort of likely normal children aged between 0 and 18 years.

METHODS

Among 4,111 children examined in the past 10 years, 917 were selected with the following inclusion criteria: (a) mild ultrasonographic hydronephrosis with right differential renal function (DRF) <53% and >47% (498 pts), (b) known or suspected urinary tract infection with normal ultrasound, serum creatinine and DMSA and DRF <53% and >47% (419 pts). (123)I-OIH-Cl was assessed using a validated gamma camera method. Children were divided into 21 age classes: from 0 to 2 years, eight 3-month classes; from 2 to 14 years, twelve 1-year classes; from 14 to 18 years, one 4-year class.

RESULTS

Cl, plotted against age, was fitted using an increasing function (y=a-be-cx). Mean (123)I-OIH-Cl of 1,834 kidneys was 306+/-22 ml/min/1.73 m(2) BSA. Mean (123)I-OIH-Cl of the right and left kidneys was 307+/-23 and 305+/-22 ml/min/1.73 m(2) BSA, respectively (p<0.002). The best-fitting (123)I-OIH-Cl growing function was: Cl=311-230e-0.69xAge (months). (123)I-OIH-Cl improved progressively starting from birth, reaching 96% and 98% of the mature value at 1 and 1.5 years, respectively. (123)I-OIH-Cl at birth (age=0) was 81 ml/min/1.73 m(2) BSA. After 18.6 days of life, the renal function had doubled its starting value, and it reached a plateau of 311 ml/min/1.73 m(2) BSA at 2 years.

CONCLUSION

This work represents a systematic evaluation of ERPF by a gamma camera method in a large cohort of selected likely normal paediatric subjects.

摘要

目的

在一大群年龄介于0至18岁的可能正常儿童中，估算（123）I-邻碘马尿酸（OIH）单肾清除率（Cl）与年龄相关的值。

方法

在过去10年接受检查的4111名儿童中，根据以下纳入标准选取了917名：（a）轻度超声肾盂积水，右肾分肾功能（DRF）<53%且>47%（498例）；（b）已知或疑似尿路感染，超声、血清肌酐和二巯基丁二酸正常，且DRF<53%且>47%（419例）。使用经过验证的γ相机方法评估（123）I-OIH-Cl。儿童分为21个年龄组：0至2岁，8个3个月的组；2至14岁，12个1岁的组；14至18岁，1个4岁的组。

结果

将Cl与年龄作图，使用递增函数（y = a - be - cx）进行拟合。1834个肾脏的平均（123）I-OIH-Cl为306±22 ml/min/1.73 m²体表面积。右肾和左肾的平均（123）I-OIH-Cl分别为307±23和305±22 ml/min/1.73 m²体表面积（p<0.002）。最佳拟合的（123）I-OIH-Cl增长函数为：Cl = 311 - 230e - 0.69×年龄（月）。（123）I-OIH-Cl从出生起逐渐改善，在1岁和1.5岁时分别达到成熟值的96%和98%。出生时（年龄 = 0）的（123）I-OIH-Cl为81 ml/min/1.73 m²体表面积。出生18.6天后，肾功能已翻倍，在2岁时达到311 ml/min/1.73 m²体表面积的平台期。