Itoh K, Tsukamoto E, Kakizaki H, Nonomura K, Furudate M
Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Nucl Med Commun. 1993 Aug;14(8):644-52. doi: 10.1097/00006231-199308000-00004.
This study was undertaken to compare image quality, renal handling and plasma clearance of 99Tcm-mercaptoacetyltriglycine (99Tcm-MAG3) with those of 123I-orthoiodohippurate (123I-OIH). 99Tcm-MAG3 was prepared in-house using an instant kit vial and 123I-OIH was commercially available in a form already labelled. Both studies were undertaken in 20 patients with nephrourological disorders after intravenous (i.v.) injection of 300 MBq 99Tcm-MAG3 and 34 MBq 125I-OIH within the time interval of 3 to 4 days. 99Tcm-MAG3 was much superior to 123I-OIH in visualization of renal perfusion, renal parenchyma and urinary tract. The time parameters of the renogram, Tmax and T1/2 were significantly prolonged in 99Tcm-MAG3 compared to those for 123I-OIH (P < 0.05). Plasma clearance of 99Tcm-MAG3 was also slower than that of 123I-OIH but correlated well with that of 123I-OIH (r = 0.958, P < 0.01). The % renal uptake of 99Tcm-MAG3 per injected dose, which was calculated by the gamma camera method, also correlated well with effective renal plasma flow (ERPF) calculated by the single blood sampling method (r = 0.940, P < 0.01). The renal handling and plasma clearance of 99Tcm-MAG3 are not completely identical with those of 123I-OIH. However, 99Tcm-MAG3 has the clinical advantages of superior image quality, the feasibility of gamma camera measurement of quantitative renal uptake, and ready availability for routine clinical use.
本研究旨在比较99锝-巯基乙酰三甘氨酸（99Tcm-MAG3）与123碘-邻碘马尿酸（123I-OIH）的图像质量、肾脏处理及血浆清除情况。99Tcm-MAG3采用即时试剂盒瓶在内部制备，123I-OIH以已标记好的形式商业可得。两项研究均在20例患有肾脏泌尿系统疾病的患者中进行，在3至4天的时间间隔内静脉注射300 MBq 99Tcm-MAG3和34 MBq 125I-OIH。在肾脏灌注、肾实质及尿路的显影方面，99Tcm-MAG3远优于123I-OIH。与123I-OIH相比，99Tcm-MAG3肾图的时间参数Tmax和T1/2显著延长（P < 0.05）。99Tcm-MAG3的血浆清除也比123I-OIH慢，但与123I-OIH的血浆清除相关性良好（r = 0.958，P < 0.01）。通过γ相机法计算的每注射剂量99Tcm-MAG3的肾脏摄取百分比，也与通过单次血样采集法计算的有效肾血浆流量（ERPF）相关性良好（r = 0.940，P < 0.01）。99Tcm-MAG3的肾脏处理及血浆清除与123I-OIH并不完全相同。然而，99Tcm-MAG3具有图像质量优越、γ相机定量测量肾脏摄取的可行性以及便于常规临床使用等临床优势。
