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Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide.

作者信息

Loeser Richard F

出版信息

Arthritis Rheum. 2006 May;54(5):1357-60. doi: 10.1002/art.21813.

DOI:10.1002/art.21813
PMID:16645963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1774815/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc1/1774815/303a373a3b9f/nihms10523f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc1/1774815/fc631bd76c14/nihms10523f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc1/1774815/303a373a3b9f/nihms10523f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc1/1774815/fc631bd76c14/nihms10523f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bc1/1774815/303a373a3b9f/nihms10523f2.jpg

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本文引用的文献

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Cellular events leading to chondrocyte death after cartilage impact injury.软骨撞击损伤后导致软骨细胞死亡的细胞事件。
Arthritis Rheum. 2006 May;54(5):1509-17. doi: 10.1002/art.21812.
2
Pathomechanisms of cartilage destruction by mechanical injury.机械损伤导致软骨破坏的病理机制。
Ann Anat. 2005 Nov;187(5-6):473-85. doi: 10.1016/j.aanat.2005.07.003.
3
Structural factors associated with malalignment in knee osteoarthritis: the Boston osteoarthritis knee study.膝关节骨关节炎中与力线不良相关的结构因素：波士顿骨关节炎膝关节研究
Front Sports Act Living. 2025 Jan 20;7:1497110. doi: 10.3389/fspor.2025.1497110. eCollection 2025.
4
Differentiation of stem cells into chondrocytes and their potential clinical application in cartilage regeneration.干细胞向软骨细胞的分化及其在软骨再生中的潜在临床应用。
Histochem Cell Biol. 2025 Jan 25;163(1):27. doi: 10.1007/s00418-025-02356-7.
5
FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway.促卵泡生成素可能通过核因子κB途径增强膝关节巨噬细胞的炎症反应。
FEBS Open Bio. 2025 Apr;15(4):622-633. doi: 10.1002/2211-5463.13959. Epub 2025 Jan 13.
6
Therapeutic Controlled Release Strategies for Human Osteoarthritis.人类骨关节炎的治疗性控释策略
Adv Healthc Mater. 2025 Jan;14(2):e2402737. doi: 10.1002/adhm.202402737. Epub 2024 Nov 6.
7
Mume Fructus reduces interleukin-1 beta-induced cartilage degradation via MAPK downregulation in rat articular chondrocytes.乌梅通过下调 MAPK 抑制白细胞介素-1β诱导的软骨降解。
PLoS One. 2024 May 8;19(5):e0302906. doi: 10.1371/journal.pone.0302906. eCollection 2024.
8
Syringic Acid Attenuates the IL-1β-Induced Akt Pathway in Chondrocyte ATDC5 Cells.丁香酸减弱白细胞介素-1β诱导的软骨细胞ATDC5细胞中的Akt信号通路。
Comb Chem High Throughput Screen. 2025;28(8):1363-1371. doi: 10.2174/0113862073286384240227053954.
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A programmable arthritis-specific receptor for guided articular cartilage regenerative medicine.一种用于引导性关节软骨再生医学的可编程关节炎特异性受体。
bioRxiv. 2024 Feb 15:2024.01.31.578281. doi: 10.1101/2024.01.31.578281.
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Biomedicines. 2023 Dec 20;12(1):9. doi: 10.3390/biomedicines12010009.
J Rheumatol. 2005 Nov;32(11):2192-9.
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An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis.一种在抑瘤素中的天冬氨酸重复多态性抑制软骨形成并增加患骨关节炎的易感性。
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Cyclic tensile stretch loaded on bovine chondrocytes causes depolymerization of hyaluronan: involvement of reactive oxygen species.加载于牛软骨细胞上的周期性拉伸会导致透明质酸解聚：活性氧的参与。
Arthritis Rheum. 2003 Nov;48(11):3151-8. doi: 10.1002/art.11305.