Déléris Paul, Gayral Stéphanie, Breton-Douillon Monique
Laboratoire de Signalisation et Croissance Cellulaire, Institut de Recherche en Immunovirologie et Cancérologie, Université de Montréal, Montréal, QC H3T 1J4 Canada.
J Cell Biochem. 2006 Jun 1;98(3):469-85. doi: 10.1002/jcb.20695.
Phosphatidylinositol 3,4,5-trisphosphate (Ptdlns(3,4,5)P(3)) is linked to a variety of cellular functions, such as growth, cell survival, and differentiation. Ptdlns(3,4,5)P(3) is primarily synthesized by class I phosphoinositide 3-kinases and its hydrolysis by two 3-phosphoinositide 3-phosphatases, PTEN and SHIP proteins, leads to the production of two other second messengers, Ptdlns(4,5)P(2) and Ptdlns(3,4)P(2), respectively. Evidence accumulated over the last years strongly suggest that Ptdlns(3,4,5)P(3) is an important component of signaling pathway operating within the nucleus. Moreover, recent advances indicated that nuclear translocation of cell surface receptors could activate nuclear phosphoinositide 3-kinase suggesting a new mode of signal transduction. The aim of this review is intended to summarize the state of our knowledge on nuclear Ptdlns(3,4,5)P(3) and its metabolizing enzymes, and to highlight the emerging roles for intranuclear Ptdlns(3,4,5)P(3).
磷脂酰肌醇-3,4,5-三磷酸（Ptdlns(3,4,5)P(3)）与多种细胞功能相关，如生长、细胞存活和分化。Ptdlns(3,4,5)P(3)主要由I类磷脂酰肌醇3-激酶合成，其被两种3-磷酸肌醇3-磷酸酶（PTEN和SHIP蛋白）水解，分别导致另外两种第二信使Ptdlns(4,5)P(2)和Ptdlns(3,4)P(2)的产生。过去几年积累的证据有力地表明，Ptdlns(3,4,5)P(3)是细胞核内运作的信号通路的重要组成部分。此外，最近的进展表明细胞表面受体的核转位可激活核磷脂酰肌醇3-激酶，提示一种新的信号转导模式。本综述的目的旨在总结我们对核Ptdlns(3,4,5)P(3)及其代谢酶的认识状况，并突出核内Ptdlns(3,4,5)P(3)新出现的作用。
