Leblanc N, Chen S, Swank P R, Levin H, Schachar R
Brain Cogn. 2006 Mar;60(2):208-9.
We examined the effect of traumatic brain injury (TBI) on inhibitory control, trajectories of recovery of inhibitory control, and the effect of age at injury, severity, and lesion location on recovery. Participants were 127 children with TBI aged 5-16 years and 117 controls of similar age. Latency of response inhibition was measured with the stop signal task within 1 month of the injury and again at 3, 6, 12, and 24 months. Performance of children with TBI was compared with that of controls. Growth curve analyses showed impairments in response inhibition postinjury. Compared with controls, TBI children improved over time in response inhibition. Younger TBI children recovered better on response inhibition than older TBI children. No significant effect of severity or right frontal lesion on recovery of response inhibition was found. TBI has an acute effect on inhibitory control but which recovers over time.
我们研究了创伤性脑损伤（TBI）对抑制控制的影响、抑制控制的恢复轨迹，以及受伤年龄、严重程度和损伤位置对恢复的影响。参与者为127名5至16岁的TBI儿童和117名年龄相仿的对照组儿童。在受伤后1个月内以及3、6、12和24个月时，使用停止信号任务测量反应抑制潜伏期。将TBI儿童的表现与对照组儿童进行比较。生长曲线分析显示受伤后反应抑制存在损伤。与对照组相比，TBI儿童的反应抑制随时间有所改善。年龄较小的TBI儿童在反应抑制方面的恢复情况优于年龄较大的TBI儿童。未发现严重程度或右侧额叶损伤对反应抑制恢复有显著影响。TBI对抑制控制有急性影响，但会随时间恢复。
