Choi Won, Park Yeon Hee, Paik Kwang Hyun, Chang Yoon Hwan, Lee Seung-Sook, Ryoo Baek-Yeol, Yang Sung Hyun
Department of Internal Medicine, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
Korean J Intern Med. 2006 Mar;21(1):57-61. doi: 10.3904/kjim.2006.21.1.57.
Hypereosinophilic syndrome (HES) is a clinical disorder characterized by persistent eosinophilia and systemic involvement, in which a specific causative factor for the eosinophilia cannot be verified during a certain period of time. There have been only a few reported cases of this syndrome associated with malignant lymphoma. We report a case of peripheral T-cell lymphoma-unspecified with hypereosinophilic syndrome. The patient was a 42-year-old woman with an uncontrolled fever and a sore throat. Eosinophilia was observed on the peripheral blood smear. We confirmed the diagnosis by bone marrow and liver biopsies:. A bone marrow aspiration demonstrated markedly increased eosinophils (24.8%), and a liver biopsy demonstrated infiltration by scattered eosinophils and atypical lymphoid cells, which were confirmed to be T-cell lymphoma cells. This case was a distinctive presentation of peripheral T-cell lymphoma with hypereosinophilic syndrome, probably due to a paraneoplastic condition.
高嗜酸性粒细胞综合征（HES）是一种以持续性嗜酸性粒细胞增多和全身受累为特征的临床疾病，在一定时期内无法证实嗜酸性粒细胞增多的特定致病因素。与恶性淋巴瘤相关的该综合征报告病例仅有少数。我们报告一例伴有高嗜酸性粒细胞综合征的外周T细胞淋巴瘤（非特指型）。患者为一名42岁女性，有持续发热和咽痛症状。外周血涂片可见嗜酸性粒细胞增多。我们通过骨髓和肝脏活检确诊：骨髓穿刺显示嗜酸性粒细胞显著增多（24.8%），肝脏活检显示有散在嗜酸性粒细胞和非典型淋巴细胞浸润，经证实为T细胞淋巴瘤细胞。该病例是外周T细胞淋巴瘤伴高嗜酸性粒细胞综合征的一种独特表现，可能是由于副肿瘤状态所致。
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